CHEMISTRY:    HOME SEARCH
Southern illinois University Edwardsville
 


Chin-Chuan Wei, Ph.D.

RESEARCH

My main research interests lie in understanding the molecular basis of protein function. Of particular interests are studies of metalloenzymes structure/function, protein electron transfer, protein-protein interactions, and receptor-ligand interactions that are involved in biological signal transduction. My current projects aim to understand the mechanism of nitric oxide (NO) synthesis by human and plant nitric oxide synthases (NOSs) and reactive oxygen species (ROS) production by non-phagocyte NADPH oxidase enzymes (NOX). NOS and NOX play important roles in the control of fundamental physiologic processes, including vascular tone, platelet function, neuron signaling, mitosis, apotosis, and cell migration. Understanding how auxiliary cellular components and factors interact with enzymes to control their biochemical reactions presents exciting challenges.

Research interests include:

  • Biochemistry of non-phagocyte NOX and DUOX

  • Structural and functional studies of plant NO synthase

  • Tetrahydrobiopterin roles in human Nitric Oxide Synthases

  • Membrane Fluidity during apoptosis (w/ Dr. Wanda Biological Science)

  • Calmodulin in STIM Ca2+ Storage and Fas Receptor


    Students currently working reaseach projects in my lab

  • Nicole Reynol (3+2 program), Sm 2009 - present, 2011S Research Grants for Graduate Students (RGGS), 2011 SIUe Bouman Awards

  • Allison Tatro (M.S.), S 2011 - present, 2011F Research Grants for Graduate Students (RGGS)

  • Megan Dickson (M.S.), S 2011 - present

  • Shubha Shakya (M.S.), F 2011 - present

  • Sahar Foroutannejad (M.S.), S 2012 - present

  • Michael Reimer, F 2010 - present, 2011 SIUe Bouman Awards, FY2012 Undergraduate Research and Creative Activities (URCA) Associates

  • Jenna Goeckner, F 2010 - present, FY2012 Undergraduate Research and Creative Activities (URCA) Associates

  • Katherine Bennett, Sm 2011 -present, 2011F UCRA Assistant

  • Christina Palka, F 2011 -present, 2012S UCRA Assistant

    Graduates (only list students performing extensive research)

    (Name; Dates Working in My Lab; Current Position; remark; Update Date)

  • Kristen Wetherell, Sp 2009 - F 2010,Medical School

  • Tiffany William, Sp 2009 - sm 2010, (2010 SIUe Bouman Award, 2010 ISAS Chemistry Awards), 08/18/2010

  • Nicol Motl, Sm 2008 - sm 2010, Ph.D. University of Michigan,(2009 NSF-Research Experience for Undergraduates (REU); 2009 Student Presentation Award from Illinois State Academy of Science (ISAS), 2009 SIUe Undergraduate Research and Creative Activities (URCA) Associates), 08/16/2010

  • Kelli levek, Sm 2008 - sp 2010,Ph.D. Washington University St. Louis, (2009 SIUe Undergraduate Research and Creative Activities (URCA) Associates, 2010 SIUe Bouman Award), 08/18/2010

  • Stephen Bux, F 2006 - Sp 2009, 2009 SIUe Bouman Award

  • Liu Qi Chen (MS); Sp 2008 - Sm 2009; Ph.D. program University of Arizona,Tucson; 2009 SIUe Research Grants for Graduate Students (RGGS) Recipient; 07/2009

  • Tremylla Johnson (MS); Sp 2007 - Sm 2008; Sigmal-Aldrich Inc.; 2008 Research Grants for Graduate Students (RGGS) Recipient & 2008 SIUe Bouman Award ; 05/2009

  • Lindsey Hamilton ; Sm 2007 - Sp 2008; School of Nursing at SIUe; 2008 Undergraduate Research Academy Scholar & 2008 SIUe Bouman Award; 06/'08

  • Dawn Powell; F 2007 - Sp 2008; Akermin Inc, St Louis; 2008 Undergraduate Research Academy Scholar; 06/'08

  • Whitney Luebben; F 2007 - Sp 2008; Ph.D. Colorado State University; 06/'08