CHEMISTRY:    HOME SEARCH

Southern illinois University Edwardsville
 


Chin-Chuan Wei, Ph.D.

RESEARCH

My main research interests lie in understanding the molecular basis of protein function. Of particular interests are studies of metalloenzymes structure/function, protein electron transfer, protein-protein interactions, and receptor-ligand interactions that are involved in biological signal transduction. My current projects aim to understand the mechanism of nitric oxide (NO) synthesis by human and plant nitric oxide synthases (NOSs) and reactive oxygen species (ROS) production by non-phagocyte NADPH oxidase enzymes (NOX). NOS and NOX play important roles in the control of fundamental physiologic processes, including vascular tone, platelet function, neuron signaling, mitosis, apotosis, and cell migration. Understanding how auxiliary cellular components and factors interact with enzymes to control their biochemical reactions presents exciting challenges.

Research interests include:

  • Biochemistry of non-phagocyte NOX and DUOX

  • Structural and functional studies of plant NO synthase

  • Tetrahydrobiopterin roles in human Nitric Oxide Synthases

  • Calmodulin in STIM Ca2+ Storage and Fas Receptor

  • Lysozyme and Chitin related projects


    Students currently working research projects in my lab

  • Nicole Kaufman (MS), Sm2015 -present

  • Kyle Schafer (ud), F2014 - present, S2015 URCA Assistant, FY2016 Undergraduate Research and Creative Activities (URCA) Associates

  • Liam O'Brien (ud), S2014 - present,

  • McKenzie Thomas (ud), F2014 - present, F2015 URCA Assistant

  • Sierra Halverson (ud), F2014 - present, F2015 URCA Assistant


    Graduates (only list students performing extensive research)

    (Name; Dates Working in My Lab; Current Position; remark; Update Date)

  • Drake Jensen (ud&MS), S2012 -2015, Ph.D. School of Medicine, Washington University at St. Louis (FY2013 Undergraduate Research and Creative Activities (URCA) Associates, 2013&2015 SIUe Bouman Research Awards)

  • Dallas Wright (ud), F2013 - S2015, S2014&F2014 URCA Assistant

  • Inoka Pathiraja (M.S.) S2013 - sm2014

  • Victoria Francis (ud) S2012 - F2014, Medical School (S2012, F2013 URCA Assistantship)

  • Sabina Ranjit (M.S.) F2012 - sm2014, Ph.D, Pharmacology, U. of Tennessee, Memphis (2014 Research Grants for Graduate Students (RGGS) award)

  • Katherine Bennett (Un, MS) , Sm2011 - s2014, 2014-present, Sigma-Aldrich, Inc. (2011F UCRA Assistant, 2012, 2014 SIUe Bouman Awards, 2013 Research Grants for Graduate Students (RGGS) award)

  • Shubha Shakya (M.S.), F2011 - Sm 2013, Industry and Ph.D. University of Virginia (2012S Research Grants for Graduate Students (RGGS))

  • Allison Tatro (M.S.), S2012 - sm2013, Sigma-Aldrich Inc. (2011F Research Grants for Graduate Students (RGGS))

  • Stephanie Bargiel (ud), Sm2012 -S2013, FY2013 (Undergraduate Research and Creative Activities (URCA) Associates)

  • Nicole Reynol (ud&MS) , Sm2009 - sm2012, Pfizer Inc. (2011S Research Grants for Graduate Students (RGGS), 2011 & 2012 SIUe Bouman Awards)

  • Christina Palka (ud), F2011 -S2012, Ph.D. UC Santa Cruz, Biomedical Science and Engineering; 2012-2014: University of Chicago (2012S UCRA Assistant, 2012 ASBMB Undergraduate Travel Award)

  • Jenna Goeckner (ud), F2010 - S2012, 2013-present, SIU Medical School, 2012-2013,The Genome Institute, Washington University School of Medicine (2012-2013) (FY2012 Undergraduate Research and Creative Activities (URCA) Associates)

  • Michael Reimer (ud), F2010 - S2012, SIUe MS program (2011 SIUe Bouman Awards, FY2012 Undergraduate Research and Creative Activities (URCA) Associates)

  • Megan Dickson (M.S.), S2011 - Sm2012, AssayPro Inc.

  • Kristen Wetherell (ud), S2009 - F2010, Medical School

  • Tiffany Boyle (ud) , S2009 - sm2010, 2010 SIUe Bouman Award, 2010 ISAS Chemistry Awards, 08/18/2010

  • Nicol Motl (ud) , Sm2008 - sm2010, Ph.D. University of Michigan, (2009 NSF-Research Experience for Undergraduates (REU); 2009 Student Presentation Award from Illinois State Academy of Science (ISAS), 2009 SIUe Undergraduate Research and Creative Activities (URCA) Associates), 08/16/2010

  • Kelli levek (ud), Sm2008 - S2010, SIU Medical School (2009 SIUe Undergraduate Research and Creative Activities (URCA) Associates, 2010 SIUe Bouman Award), 08/18/2010

  • Stephen Bux, F2006 - S2009, 2009 SIUe Bouman Award

  • Liu Qi Chen (MS); S2008 - Sm2009; Ph.D. program University of Arizona,Tucson; 2009 SIUe Research Grants for Graduate Students (RGGS) Recipient; 07/2009

  • Tremylla Johnson (MS); Sp 2007 - Sm 2008; Sigmal-Aldrich Inc. Currently in UCLA; 2008 Research Grants for Graduate Students (RGGS) Recipient & 2008 SIUe Bouman Award ; 05/2009

  • Lindsey Hamilton (ud); Sm 2007 - Sp 2008; School of Nursing at SIUe; 2008 Undergraduate Research Academy Scholar & 2008 SIUe Bouman Award; 06/'08

  • Dawn Powell (ud) ; F 2007 - Sp 2008; Akermin Inc, St Louis; 2008 Undergraduate Research Academy Scholar; 06/'08

  • Whitney Luebben (ud); F 2007 - Sp 2008; Ph.D. Colorado State University; 06/'08