Yun Lu, Ph.D.

Associate Professor - Organic Chemistry

Department of Chemistry

College of Arts and Sciences,

Southern Illinois University at Edwardsville,
2337 Science Building,

Edwardsville, Illinois 62026-1652.


Office Phone: 618-650-3563

Fax: 618-650-3556




Working Experience











Ph.D.,  Organic Chemistry, 1996, Nankai University

M.S.,   Organic Chemistry, 1991, Shanxi University

B.S.,    Chemistry, 1986, Shanxi University

Working Experience:

Assistant Professor, Southern Illinois University Edwardsville, 2004 - present

Research Assistant Professor, Utah State University, 2003-2004

Postdoctoral research fellow, Utah State University, 1998-2000, 2001-2003

Postdoctoral research fellow, Wayne State University, 2000-2001

Faculty, Nankai University, 1996-1997; Taiyuan University of Technology, 1991-1993; Shanxi Medical University, 1986-1988


Research Interests:

My overall research centers on the mechanistic understandings of organic and biology-related reactions employing mechanistic analysis methodologies. Current research includes three projects, (i) structure-reactivity-mechanism relationship for hydride transfer reactions from alcohols to oragnic cations, (ii) biomimetic chemistry studies of the alcoholic oxidations by NAD+ coenzyme mediated by alcohol dehydrogenases, and (iii) enhanced reactivity of hydroxide ion in water containing cyclodextrin.



Organic chemistry 241a and 241b

The Organic chemistry of Enzyme Catalyzed Reactions 549

Graduate Seminar 575

Organic Lab 245 (coordinating)

General, Organic and Biol Chem Lab 124B (coordinating)

Nursing Chemistry Lab 124A (coordinating)



41.       Yun Lu*, Joshua Bradshaw, Yu Zhao, William Kuester, Daniel Kabotso “Structure-Reactivity Relationship for Alcohol Oxidations via Hydride Transfer to a Carbocationic Oxidizing Agent" J. Phy. Org. Chem. 2011, in press.

40.       Yufang Liu, Bo Liu*, Ailing Guo, Zhenming Gong, Shou Jin, Yun Lu “Reduction of Nitroarenes to Azoxybenzenes by NaOH-PEG 400" Syn. Comm. 2011, in press.

39.       Yu-Fang Liu, Bo Liu*, Zhen-Ming Dong, Shou Jin, Cai-Yun Liang, Rui-Tao Zhu, Yun Lu “New Method for Preparation of Azoxybenzenes" Chem. J. Chinese Universities 2010, 31, 2396-2399.

38.       Yun Lu*, Fengrui Qu, Yu Zhao, Ashia M. J. Small, Joshua Bradshaw, Brain Moore “Kinetics of the Hydride Reduction of an NAD+ Analogue by Isopropyl Alcohol in Aqueous and Acetonitrile Solutinos: Solvent Effects, Deuterium Isotope Effects, and Mechanism" J. Org. Chem. 2009, 74, 6503-6510.

37.       Yun Lu*, Fengrui Qu, Brian Moore, Donald Endicott, William Kuester “Hydride Reduction of NAD+ Models by Isopropyl Alcohol: Kinetics, Deuterium Isotope Effects and Mechanism" J. Org. Chem. (Featured Article) 2008, 73, 4763-4770.

36.       Yun Lu*, Donald Endicott, William Kuester “Effective Thermal Oxidation of Isopropanol by an NAD+ model.” Tetrahedron Letters 2007, 48, 6356-6359.

35.       Yun Lu*, Jiancheng Liu, Garry Diffee, Diansheng Liu, Bo Liu* “Reduction of Nitroarenes by Hydroxide Ion in Water Catalyzed by β-Cyclodextrin: Enhanced Reactivity of Hydroxide Ion.” Tetrahedron Letters 2006, 47, 4597-4599.

(Above publications were based on the work at Southern Illinois University Edwardsville)

34.       Vernon D. Parker, Yun Lu, Yixing Zhao  “Proton Transfer Reactions of Methylanthracene Radical Cations with Nitrogen-Centered Bases under Non-Steady-State Conditions.  A Search for the Possible Effect of Reactant Impurities upon the Kinetic Data.” J. Org. Chem. 2005, 70, 1350.

33.       Kishan L. Handoo, Yun Lu, Vernon D. Parker “Resolution of the Non-steady-state kinetics of the 2-step mechanism for the Diels-Alder reaction between anthracene and tetracyanoethylene in Acetonitrile” J. Am. Chem. Soc.  2003, 125, 9381.

32.       Yun Lu, Kishan L. Handoo, Vernon D. Parker “Non-steady-state study of the SN2 reaction between 4-nitrophenoxide ion and methyl iodide in aprotiuc solvents containing water. Evidence for a 2-step mechanism” Org. Biomol. Chem.  2003, 1, 36.

31.       Vernon D. Parker, Yun Lu  Non-steady-state kinetic study of the SN2 reaction between p-nitrophenoxide ion and methyl iodide in acetonitrileOrg. Biomol. Chem. 2003, 1, 2621.

30.       Yun Lu, Yixing Zhao, Kishan L. Handoo, Vernon D. Parker “Hydride-exchange reactions between NADH and NAD+ model compounds under non-steady-state conditions. Apparent and Real kinetic isotope effects” Org. Biomol. Chem. 2003, 1, 173.

29.       Meng-Sheng Liao, Yun Lu, Vernon D. Parker, Steve Scheiner “DFT calculations and spectral measurements of charge-transfer complexes formed by aromatic amines and nitrogen heterocycles with tetracyanoethylene and with chloranil” J. Phys.Chem. A 2003, 107, 8939.

28.       Kishan L. Handoo, Yun Lu, Yixing Zhao, Vernon D. Parker “Resolution of the non-steady-state kinetics of the elimination of HBr from 2-(4-nitrophenyl)ethyl bromide in alcohol/alkoxide media)” Org. Biomol. Chem.  2003, 1, 24.

27.       Meng-Sheng Liao, Yun Lu, Steve Scheiner “Performance of Density-Functional Methods for Charge-Transfer Complexes” J. Comput. Chem. 2003, 24, 623.

26.       Martin Newcomb, Runnan Shen, Yun Lu, Minor J. Conn, Paul F. Hollenberg, Daniel A. Kopp, Stephen J. Lippard  “Evaluation of norcarane as  a probe for radicals in cytochrome P-450 and soluble Methane Monooxygenase- catalyzed hydroxylation reactions” J Am. Chem. Soc. 2002, 124, 6879.

25.       Yun Lu, Yixing Zhao, Vernon D. Parker “Proton-transfer reactions of methylarene radical cations with pyridine bases under non-steady-state conditions. Real kinetic isotope effect evidence for extensive tunneling” J Am. Chem. Soc. 2001, 123, 5900.

24.       Yixing Zhao, Yun Lu, Vernon D. Parker “Proton-transfer reactions between nitroalkanes and hydroxide ion under non-steady-state conditions. Apparent and real kinetic isotope effects” J Am. Chem. Soc. 2001, 123, 1579.

23.       Vernon D. Parker, Yixing Zhao, Yun Lu “Non-steady-state kinetics of the reactions of electrode generated intermediates. Resolution of the kinetics of proton transfer reactions of methylene radical cations.” Electrochemical Society Proceedings, 2001, 14, 1.

22.       Yixing Zhao, Yun Lu, Vernon D. Parker “Non-Steady-State Kinetic Studies of the Real Kinetic Isotope Effects and Arrehenius Activation Parameters for the Proton Transfer reactions of 9,10-Dimethylanthrance Radical Cation with Pyridine Bases” J Chem Soc, Perkin Trans 2. 2001, 1481.

21.       Jin-Pei Cheng, Yun Lu, Xiaoqing Zhu,Shun Yongkai, Feng Bi, He, Jiaqi  “Hetereolytic and Homolytic N-H Bond Dissociation Energies of 4-Substituted Hantzch2,6-dimethyl-1,4-dihydro-pyridines and the Effect of One-electron Transfer on the N-H Bond Activation” J. Org. Chem. 2000, 65, 3853.

20.       Bingjun Zhao, Xiaoqing Zhu, Yun Lu, Chizhong Xia, Jin-Pei Cheng “Kinetics and Mechanistic investigation on the Oxidation of Hantzsch 1,4-Dihydropyridines with the Tropylium Cation: A Model for NADH Oxidation.” Tetrahydron Lett. 2000, 41, 257.

19.       Yun Lu, Ming Xian, Xiaoqing Zhu, Kun Wang, Linjing Mu, Jin-Pei Cheng “Studies on the Structure-Activity Relationship of NAD(P)H Models: Electronic Effects of 3-Acyls” J. Chem. Chinese Univ. 1999, 19, 59.

18.       Jin-Pei Cheng, Bo Liu, Yongyu Zhao, Yongkai Sun, Xian-Man Zhang, Yun Lu,  “Effects of Adjacent Onium Cations and Remote Substituents on the H-A+ Bond Equilibrium Acidities in Dimethyl Sulfoxide Solution. An Extensive Ylide Thermodynamic Stability Scale and Implication for the Importance of Reasonance effect on Ylide Stabilities.” J Org. Chem. 1999, 64, 604.

17.       Jin-Pei Cheng, Yun Lu, Xiaoqing Zhu, LinJing Mu “Energetics of Multi-step vs. One-step Hydride Transfer Reactions of Reduced Nicotinamide Adenine Dinucleotide (NADH) Models with Organic Cations and p-Quinones” J. Org. Chem. 1998, 63, 6108.

16.       Vernon D. Parker, Yixing Zhao, Yun Lu, Gang Zheng “Application of Non-Steady-State Kinetics to Resolve the Kinetics of Proton Transfer Reactions between Methylarene Radical Cations and Pyridine Bases” J Am. Chem. Soc. 1998, 120, 12720.

15.       Jin-Pei Cheng, Kun Wang, Zheng Yin, Xiaoqing Zhu, Yun Lu “NO Affinity. The Driving force of Nitric Oxide (NO) Transfer in Biomimetic N-nitrosoacetanilide and N-nitrososulfoanilide Systems” Tetrahedron Lett.  1998, 39, 7925.

14.       Jin-Pei Cheng, Yun Lu, Bo Liu, Yongyu Zhao, Yongkai Sun, Difei Wang, Jianglin Mi “Effects of Double Substitution of the Thermodynamic Stabilities of Nitrogen Radicals” Science in China (series B)(Engl) 1998, 41, 215.

13.       Hongxing Wang, Jin-Pei Cheng, Wenxiang Gu, Gaojiu Zhang, Zhenwei Huan, Yun Lu “Reactions of fluorocarbenes with carbonyl compounds - The effects of para-substituents and pre-aromatic character on deoxygenation of aryl aldehydes and tetraphenyl-cyclopentadienone” J. Chem. Chinese Univ. 1998, 19(8), 723.

12.       Yun Lu, Duan Liu, Bingjun Zhao, Xiaoqing Zhu, Jin-Pei Cheng “Bond Dissociation Energies of N(C)-H Bond Cleavage of Substituted-1,4-dihydro-Hantzsch Pyridines and Corresponding Ion Radicals: An Application on the Mechanistic Studies of Hantzsch Ester Mediated Reductions” J. Chem. Chinese Univ. (suppl.)  1998, 19(8), 432.

11.       Jin-Pei Cheng, Yun Lu “Kinetic, Thermodynamic and Mechanistic Studies on the Reduction of Carbenium Ions by NAD(P)H Analogues” J. Phys. Org. Chem.  1997, 10, 577-584.

10.       Yun Lu, Bo Liu, Jin-Pei Cheng “Studies on the Thermodynamics and Mechanism of the Acid-Catalysed Reductions of N-arylfluoreneimines by NAD(P)H Models”