TIMOTHY B. PATRICK
Distinguished Research Professor Phone: 618-650-3582
Department of Chemistry Fax: 618-650-3556
Southern Illinois University email: tpatric@siue.edu
Edwardsville, IL 62026-1652
EDUCATION AND EXPERIENCE:
Post-Ph.D. 1967-1969 Ohio State University
Ph.D. 1963-1967 West Virginia University
B.S. 1959-1963 Marshall University
2006-1985 Promoted to Distinguished Research Professor of Chemistry
Southern Illinois University at Edwardsville
1984-1985 Sabbatical leave spent at Washington University Medical School,
Department of Nuclear Medicine, St. Louis, Missouri
1976-2006 Professor, Department of Chemistry, Southern Illinois
University at Edwardsville (SIUE)
1977-1978 NIH Trainee in Reproductive Biology, Washington University
Medical School, St. Louis, Missouri
1976-1977 Sabbatical Leave spent at Washington University Medical School,
St. Louis, Missouri, Department of Obstetrics and Gynecologog
1972-1976 Associate Professor, Department of Chemistry, SIUE
1969-1972 Assistant Professor, Department of Chemistry, SIUE
1967-1969 NSF Post-Ph.D. Fellow, Ohio State University (with Dr. M.S.
Newman)
SPECIAL INTERESTS:
Research in organofluorine chemistry. New and improved methodology for
selectively introducing fluorine into organic molecules, designing fluorinated
synthons, and developing substrates for F-18 radiolabeling. Member of the
Fluorine Division of the American Chemical Society.
Research in organic synthetic methods with the involvement of reactive
intermediates, including carbenes, diazonium, and diazo species, aryl tri-
azenes, and free radicals.
Application on NMR spectroscopy in structure spectral relationships.
Studies in F-19 and N-15 NMR spectra of research samples. Coordination of
magnetic resonance facility at SIUE.
Teaching of experimental methods in organic chemistry. Developed the
undergraduate organic microscale laboratory curriculum for all undergraduate
students at SIUE.
Bio-Organic Chemistry. Development of fluorinated systems for the study
of biological mechanisms of activity.
PAPERS PRESENTED:
1. P.H. Patrick, T.B. Patrick, and W.J. Probst, "Eu(dpm)3-Induced Proton
Shifts of of Some Benzocycloalkenols," ISAS Newsletter 4, 8 (1972)
2. M.E. Hoel, T.B. Patrick, and W.J. Probst, "The Photocyclization of Meta-
Substituted Stilbenes," ISAS Newsletter 4, 8 (1972)
3. P.H. Patrick and T.B. Patrick, "The Effect of Eu(dpm)3 on the PMR Spectra
of Benzocyclopenten-2-ol and Benzocyclobuten-1-ol," Midwest ACS
Meeting, November (1972)
4. J.A. Schield, T.B. Patrick, and W.J. Probst, "Synthesis of Fluoroaromatic
Amines," ISAS Newsletter 5, 6 (1973)
5. T.B. Patrick and G.H. Kovitch, "Photolysis of Diethyl Mercurybisdiazoacetate
and Ethyl Diazoacetate in Chloroalkanes," 10th Midwest ACS Meeting, Iowa
City, Iowa, November (1974)
6. T.B. Patrick, M.A. Dorton, and J.G. Dolan, "Thioxanthenylidene: A Nucleo-
philic Carbene," 13th Midwest ACS Meeting, Rolla, MO, November (1977)
7. F. Sweet, T. Patrick, and R. Judd, "Synthesis and Testing of a New Estro-
genic Molecular Probe," Society for Gynecological Investigation (1979)
8. T.B. Patrick, G.L. Cantrell, and S.M. Inga, "Reactions of Diarylethylenes
and Diarylimines with CF3OF," 15th Midwest ACS Meeting, St. Louis, MO,
November (1979)
9. T.B. Patrick, G.L. Cantrell, J.J. Scheibel, and D. Flory, "Fluorination of
Diazo Compounds," 17th Midwest ACS Meeting, Columbia, MO, November (1981)
10. T.B. Patrick, K.H. Johri, and D.H. White, "Fluoro-decarboxylation with
Xenon Difluoride," National ACS Meeting, St. Louis, MO, May (1984)
11. T.B. Patrick, M.R. Kilbourn, M.J. Welch, "A New Route to F-18
Radiopharmaceuticals," 32nd Annual Meeting for the Society of
Nuclear Medicine, Houston, TX, June (1985)
12. T.B. Patrick, W.B. Bertrand, R. Mokhtar, K. Johri, D.H. White, "Replacement
of the Carboxylic Acid Function with Fluorine," Seventh Winter Fluorine
Conference, American Chemical Society, Orlando, FL, February (1985)
13. T.B. Patrick, D. DeGonia, R.P. Willaredt, "Aryltriazenes in Organic
Synthesis," 19th American Chemical Society Midwest Meeting, Springfield,
MO, November (1985)
14. M.R. Kilbourn, J.W. Brodack, D.Y. Chi, P.A. Jerabek, J.A. Katzenellenbogen,
T.B. Patrick, M.J. Welch, "F-18-Fluoride Ion: Versatile Reagent for
Radiopharmaceutical Synthesis." 33rd Annual Meeting for the
Society of Nuclear Medicine, Washington, DC, June (1986)
15. T.B. Patrick, K. Johri, B. Bertrand, "Mechanisms in Fluorodecarboxylation,"
20th American Chemical Society Midwest Meeting, Carbondale, IL, November
(1986)
16. T.B. Patrick, S. Nadji, D. Rief, "Mechanism, Structure and Stereochemistry
in Fluorodecarboxylation," Eighth Winter Fluorine Conference, American
Chemical Society, St. Petersburg, FL, February (1987)
17. T.B. Patrick and S. Nadji, "Carbanion Fluorination with Xenon Difluoride
Sulfur II," National American Chemical Society Meeting, New Orleans, LA,
August, 1987
18. T.B. Patrick, S. Bains, S. Hosseini,"Alpha-Fluoroaldehydes from a
Fluoromethyloxazoline", American Chemical Society National Meeting,
Boston, MA, April, 1990.
19. T.B. Patrick, S. Nadji, S. Khazaeli, K. Hering-Smith, "Mechanistic Studies
of Fluorodecarboxylation, " Eleventh Winter Fluorine Conference,
American Chemical Society, St. Petersburg, FL. February (1993)
20. T.B. Patrick, B. Neal, Y. Zhu, M. Lanahan, "Synthesis and Reactions of Two
New Fluoroalkenes," Twelth Winter Fluorine Conference, American Chemical
Society, St. Petersburg, FL. January (1995).
21. T.B. Patrick, L. Zhang, Q. Li, "Rearrangements in Deiodinative Fluorination",
Thirteenth Winter Fluorine Conference, American Chemical Society.
St. Petersburg, Florida, (1997).
22. T.B. Patrick, L. Zhang, Q. Li, S.Qian,"Gem-Difluoro Compounds
from the Rearrangement of Alkyl Iodides with Xenon Difluoride",
Fifteenth Winter Fluorine Conference, American Chemical
Society, St.Petersburg, Florida, (1999).
23. T. B Patrick, C. Fianu, E. Pak, B. Neal, K. Zaksas, "Some New
Fluorinated Dienophiles",
21st Winter Fluorine Conference,
American Chemical Society. St. Petersburg, Florida (2005).
24. T. B. Patrick, K. Gorrell, J. Rogers, H. Yu, D. Taylor
"Fluorinated Dienes in the Diels-Alder Reaction",
21st Winter Fluorine Conference,
American Chemical Society. St. Petersburg, Florida (2005).