<h2></h2>
<h2>Available SIUE Technologies<br /></h2>
<ul>
<li><a href="#Celik">Serdar Celik, Chris Euler, and Mehmet Kural</a><br /><em>A Combined-Loop Magnetic Refrigerator<br /></em></li>
<li><a href="#Witt">Ken Witt, Michael Crider, Karen Sandoval</a> <br /><em>Novel Drugs for Treatment of Alzheimer's Disease<br /></em></li>
<li><a href="#Noble">Bradley Noble and Michael Shaw</a><br /><em>An Inexpensive, Programmable Potentiostat for Teaching and Research Applications<br /></em></li>
<li><a href="#Navarre">Bradley Noble and Edward Navarre</a><br /><em>Portable Electrothermal Elemental Analyzer for Clinical Applications</em><br /></li>
<li><a href="#Engel">George Engel, Jerome Cox, David Zar</a><br /><em>Methods to Reduce the Design Time of Integrated Circuits<br /></em></li>
<li><a href="#Worthi1">Ronald Worthington</a><br /><em>Bacteriophage Derived Methods to Control Lactic Acid Bacterial Growth<br /></em></li>
<li><a href="#Neumann">William Neumann, Smita Rausaria, and Daniela Salveminin</a><br /><em>Discovery of Orally Active Peroxynitrite Reductase Catalysts For Treating Chronic Pain<br /></em></li>
<li><a href="#Glassman">Jack Glassman</a><br /><em>Phase-preserving Amplifier for a Stellar Interferometer</em></li>
</ul>
<p></p>
<table border="1" width="100%" cellspacing="2" cellpadding="1" align="left">
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<td width="143" height="7" bgcolor="#808080" valign="top"></td>
<td width="1106" height="7" bgcolor="#808080" valign="top"></td>
</tr>
<tr>
<td width="143" valign="top"><strong>Title:</strong></td>
<td width="1106" valign="top"><strong><a name="Celik"><em>A Combined-Loop Magnetic Refrigerator</em></a></strong></td>
</tr>
<tr>
<td width="143" valign="top"><strong>Project Leaders:</strong></td>
<td width="1106" valign="top">Serdar Celik, Chris Euler, and Mehmet H. Kural</td>
</tr>
<tr>
<td width="143" valign="top"><strong>Unit:</strong></td>
<td width="1106" valign="top">Mechanical Engineering (SIUE)</td>
</tr>
<tr>
<td width="143" valign="top"><strong>Executive Summary:</strong></td>
<td width="1106" valign="top">This invention is related to a magnetic refrigerator where a magnetocaloric material is used which heats up when a magnetic field applied on it and cools down when the magnetic field is removed. In a general reciprocating magnetic refrigerator, a heat transfer fluid which is driven by a circulation pump flows through a heat exchanger-magnetocaloric material assembly and absorbs the heat when the material heats up. Due to space restrictions, heat exchanger designs are limited to compact models. The invention involves a compact and efficient heat exchanger along with a solenoid valve so that a compact magnetic refrigerator is achieved. In this invention, the warm and cold sides of the cycle are combined using a solenoid valve so that the one single loop is shared by both warm and cold fluids. Hence less space is occupied making it feasible for magnetic refrigeration systems to be applied to domestic refrigerators.</td>
</tr>
<tr>
<td width="143" valign="top"><strong>Patent Status:</strong></td>
<td width="1106" valign="top">Provisional patent application no. 61/260,138, filed November 11, 2009. Patent application no. PCT/US10/44079, filed August 2, 2010.</td>
</tr>
<tr>
<td width="143" valign="top"><strong>Contact:</strong></td>
<td width="1106" valign="top">Christa Johnson, Associate Dean for Research, (618) 650-2171.</td>
</tr>
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<td width="143" valign="top" bgcolor="#808080" height="7"></td>
<td width="1106" valign="top" bgcolor="#808080" height="7"></td>
</tr>
<tr>
<td width="143" valign="top"><strong>Title:</strong></td>
<td width="1106" valign="top"><strong><a name="Neumann"><em>Discovery of Orally Active Peroxynitrite Reductase Catalysts For Treating Chronic Pain</em></a></strong></td>
</tr>
<tr>
<td width="143" valign="top"><strong>Project Leaders:</strong></td>
<td width="1106" valign="top">Bill Neumann (SIUE), Smita Rausaria (SIUE), and Daniela Salvemini (SLU)</td>
</tr>
<tr>
<td width="143" valign="top"><strong>Unit:</strong></td>
<td width="1106" valign="top">School of Pharmacy (SIUE)</td>
</tr>
<tr>
<td width="143" valign="top"><strong>Executive Summary:</strong></td>
<td width="1106" valign="top">One third of Americans suffer from some form of chronic pain, (30% being resistant to analgesic therapy), making it a significant health problem with serious economic impact (estimated cost of approximately $100 billion annually). Chronic pain associated with inflammatory diseases such as rheumatoid arthritis and chronic neuropathic pain is often difficult to treat in the clinic due to insufficient understanding of the nociceptive pathways involved. Current drug regimens are marginally effective and often display unacceptable side effects. Over the past decade, our multidisciplinary team has produced experimental results which clearly implicate the overproduction of peroxynitrite as a key mediator of inflammatory and chronic pain states in addition to the development of morphine-induced hyperalgesia and antinociceptive tolerance. Thus, the direct scavenging of this neurotoxic entity by small molecule drugs which act in enzyme-like catalytic fashion provides an unconventional approach to a completely novel analgesic strategy.</td>
</tr>
<tr>
<td width="143" valign="top"><strong>Brief Description:</strong></td>
<td width="1106" valign="top">This invention relates to our design and synthesis of new membrane-permeable and orally active transition metal complexes which behave as catalysts for the decomposition and/or reduction of peroxynitrite in vivo.</td>
</tr>
<tr>
<td width="143" valign="top"><strong>Patent Status:</strong></td>
<td width="1106" valign="top">U.S. Patent Application filed Sept 8. 2010</td>
</tr>
<tr>
<td width="143" valign="top"><strong>Contact:</strong></td>
<td width="1106" valign="top">Christa Johnson, Associate Dean for Research, (618) 650-2171.</td>
</tr>
<tr>
<td width="143" valign="top" bgcolor="#808080" height="7"></td>
<td width="1106" valign="top" bgcolor="#808080" height="7"></td>
</tr>
<tr>
<td width="143" valign="top"><strong>Title:</strong></td>
<td width="1106" valign="top"><strong><a name="Glassman"><em>Phase-Preserving Amplifier for a Stellar Interferometer</em></a></strong></td>
</tr>
<tr>
<td width="143" valign="top"><strong>Project Leaders:</strong></td>
<td width="1106" valign="top">Jack Glassman</td>
</tr>
<tr>
<td width="143" valign="top"><strong>Unit:</strong></td>
<td width="1106" valign="top">Department of Physics (SIUE)</td>
</tr>
<tr>
<td width="143" valign="top"><strong>Executive Summary:</strong></td>
<td width="1106" valign="top">A phase-preserving amplification system for stellar interferometers is disclosed. In one embodiment, a pair of crystals are provided that are configured to receive an optical signal from a source such as a telescope. A pump inputs a high energy field into the crystals, amplifying the optical signals using optical parametric amplification (OPA). A beam combiner receives and combines the amplified signals and a data collection element collects the combined amplified signals.</td>
</tr>
<tr>
<td width="143" valign="top"><strong>Patent Status:</strong></td>
<td width="1106" valign="top">U.S. Patent No. 7,154,608, issued December 26, 2006.</td>
</tr>
<tr>
<td width="143" valign="top"><strong>Contact:</strong></td>
<td width="1106" valign="top">Christa Johnson, Associate Dean for Research, (618) 650-2171.</td>
</tr>
<tr>
<td width="143" valign="top" bgcolor="#808080" height="7"></td>
<td width="1106" valign="top" bgcolor="#808080" height="7"></td>
</tr>
<tr>
<td width="143" valign="top"><strong>Title:</strong></td>
<td width="1106" valign="top"><strong><a name="Engel">EDA Tools for Reducing the Design Time of Integrated Circuits</a></strong></td>
</tr>
<tr>
<td width="143" valign="top"><strong>Project Leaders:</strong></td>
<td width="1106" valign="top">George Engel (SIUE), Jerome Cox (Washington University St. Louis), David Zar (Washington University St. Louis)</td>
</tr>
<tr>
<td width="143" valign="top"><strong>Unit:</strong></td>
<td width="1106" valign="top">Electrical and Computer Engineering</td>
</tr>
<tr>
<td width="143" valign="top"><strong>Executive Summary:</strong></td>
<td width="1106" valign="top">Blended Integrated Circuit Systems (Blendics, LLC) is based in St. Louis, MO and was founded in July 2007. The company is an outgrowth of collaborative research conducted at SIUE and Washington University. Blendics is developing revolutionary Electronic Design Automation (EDA) tools called ClosureACE and MetaACE which will greatly shrink the time required to design large, complex “System on Chips” (SoCs) while at the same time increasing the reliability of these systems. The design tools dramatically reduce the time spent by designers verifying that large complex electronic circuits meet all timing constraints. It is estimated that current design practices and design tools will fail by 2015 when transistor counts approach the 15 billion mark. In an EDA industry with a voracious appetite for acquisitions, Blendics products provide an exciting and disruptive solution to an exploding problem which in turn promises significant return on investment opportunities for investors.</td>
</tr>
<tr>
<td width="143" valign="top"><strong>Patent Status:</strong></td>
<td width="1106" valign="top">PCT/US2005/009990</td>
</tr>
<tr>
<td width="143" valign="top"><strong>Contact:</strong></td>
<td width="1106" valign="top">Christa Johnson, Associate Dean for Research, (618) 650-2171.</td>
</tr>
<tr>
<td width="143" bgcolor="#808080" height="7" valign="top"></td>
<td width="1106" bgcolor="#808080" height="7" valign="top"></td>
</tr>
<tr>
<td width="143" valign="top"><strong>Title:</strong></td>
<td width="1106" valign="top"><strong><a name="Witt">Novel Drugs for Treatment of Alzheimer's Disease</a></strong></td>
</tr>
<tr>
<td width="143" valign="top"><strong>Project Leaders:</strong></td>
<td width="1106" valign="top">Ken Witt, Michael Crider, Karen Sandoval</td>
</tr>
<tr>
<td width="143" valign="top"><strong>Unit:</strong></td>
<td width="1106" valign="top">School of Pharmacy (SIUE)</td>
</tr>
<tr>
<td width="143" valign="top"><strong>Executive Summary:</strong></td>
<td width="1106" valign="top">The treatment of Alzheimer’s Disease (AD) has shown to be an extremely difficult task, as current medications are ineffective in managing long-term symptoms, and do not halt the progression of the disease. The brains of AD sufferers exhibit various pathological features, the most prominent being amyloid or ‘senile’ plaques. Amyloid plaques consist of extracellular deposits of insoluble amyloid-ß peptide (Aß), and act as a pathological trigger culminating in neuronal death and dementia. A promising avenue for treating AD is to enhance the breakdown for such Aß deposits. With this understanding we are investigating the use of novel drugs that may enhance the breakdown of such deposits and reduce the memory loss. Our hope is that such drugs may provide a viable long-term treatment that can prevent disease progression.</td>
</tr>
<tr>
<td width="143" valign="top"><strong>Patent Status:</strong></td>
<td width="1106" valign="top">U.S. Provisional Patent Application 61/252,506 filed.</td>
</tr>
<tr>
<td width="143" valign="top"><strong>Contact:</strong></td>
<td width="1106" valign="top">Christa Johnson, Associate Dean for Research, (618) 650-2171.</td>
</tr>
<tr>
<td width="143" bgcolor="#808080" valign="top"></td>
<td width="1106" bgcolor="#808080" valign="top"></td>
</tr>
<tr>
<td width="143" valign="top"><strong>Title:</strong></td>
<td width="1106" valign="top"><em><strong><a name="Navarre">Portable Electrothermal Elemental Analyzer for Clinical Applications</a></strong></em></td>
</tr>
<tr>
<td width="143" valign="top"><strong>Project Leaders:</strong></td>
<td width="1106" valign="top">Bradley Noble and Edward Navarre</td>
</tr>
<tr>
<td width="143" valign="top"><strong>Unit:</strong></td>
<td width="1106" valign="top">Electrical and Computer Engineering; Department of Chemistry (SIUE)</td>
</tr>
<tr>
<td width="143" valign="top"><strong>Executive Summary:</strong></td>
<td width="1106" valign="top">
Drs. Noble and Navarre will present a prototype of an inexpensive, portable elemental analyzer designed to measure toxic heavy metals in clinical samples for locations that lack the funding or infrastructure for traditional instruments.
<p>The analyzer is able to provide faster analysis than competing instruments through the use of a tungsten filament, driven by a power-controlled electrical supply, that is used to heat a sample until it atomizes. Measurement is performed by atomic absorption spectrometry, monitoring the amount of light that the sample atoms absorb at characteristic wavelengths for each element. The unique features of this system are its portability and use of intelligent feedback in the atomizer circuit. The power supply uses a microcontroller for all temperature programming and monitoring functions. The system exploits this feedback loop to automate various functions of the atomizer and to enhance the quantitative data that it collects.</p>
</td>
</tr>
<tr>
<td width="143" valign="top"><strong>Patent Status:</strong></td>
<td width="1106" valign="top">Seeking licensing opportunities.</td>
</tr>
<tr>
<td width="143" valign="top"><strong>Contact:</strong></td>
<td width="1106" valign="top">Christa Johnson, Associate Dean for Research, (618) 650-2171.</td>
</tr>
<tr>
<td width="143" bgcolor="#808080" height="7" valign="top"></td>
<td width="1106" bgcolor="#808080" height="7" valign="top"></td>
</tr>
<tr>
<td width="143" valign="top"><strong>Title:</strong></td>
<td width="1106" valign="top"><strong><a name="Noble"><em>An Inexpensive, Programmable Potentiostat for Teaching and Research Applications</em></a></strong></td>
</tr>
<tr>
<td width="143" valign="top"><strong>Project Leaders:</strong></td>
<td width="1106" valign="top">Bradley Noble and Micheal Shaw</td>
</tr>
<tr>
<td width="143" valign="top"><strong>Unit:</strong></td>
<td width="1106" valign="top">Electrical and Computer Engineering; Department of Chemistry (SIUE)</td>
</tr>
<tr>
<td width="143" valign="top"><strong>Executive Summary:</strong></td>
<td width="1106" valign="top">Research in fuel cell and solar cell technology requires the use of a "potentiostat", i.e. a device which can measure current output at carefully controlled electrical potentials. Our work has been to use inexpensive, programmable PSOC chips to design and demonstrate working models of digital potentiostats. Inexpensive yet high-quality potentiostats would benefit both research and education applications: hands-on experience with real electrochemical systems from the high-school through college level would lead to a generation with fundamental understanding of how energy-producing cells work.</td>
</tr>
<tr>
<td width="143" valign="top"><strong>Patent Status:</strong></td>
<td width="1106" valign="top">Pending</td>
</tr>
<tr>
<td width="143" valign="top"><strong>Contact:</strong></td>
<td width="1106" valign="top">Christa Johnson, Associate Dean for Research, (618) 650-2171.</td>
</tr>
<tr>
<td width="143" bgcolor="#808080" height="7" valign="top"></td>
<td width="1106" bgcolor="#808080" height="7" valign="top"></td>
</tr>
<tr>
<td width="143" valign="top"><strong>Title:</strong></td>
<td width="1106" valign="top"><strong><a name="Worthi1"><em>Bacteriophage Derived Methods to Control Lactic Acid Bacterial Growth</em></a></strong></td>
</tr>
<tr>
<td width="143" valign="top"><strong>Project Leaders:</strong></td>
<td width="1106" valign="top">Ronald Worthington</td>
</tr>
<tr>
<td width="143" valign="top"><strong>Unit:</strong></td>
<td width="1106" valign="top">School of Pharmacy (SIUE)</td>
</tr>
<tr>
<td width="143" valign="top"><strong>Executive Summary:</strong></td>
<td width="1106" valign="top">The invention relates to novel antibacterial proteins and nucleic acid sequences. Specifically, the invention includes antibacterial protein compositions, methods of use, and transgenic organisms encompassing the antibacterial proteins.</td>
</tr>
<tr>
<td width="143" valign="top"><strong>Patent Status:</strong></td>
<td width="1106" valign="top">PCT Patent Application Serial No. PCT/US2009/065569.</td>
</tr>
<tr>
<td width="143" valign="top"><strong>Contact:</strong></td>
<td width="1106" valign="top">Christa Johnson, Associate Dean for Research, (618) 650-2171.</td>
</tr>
</table>
<p></p>
<p></p>
<p></p>
<p></p>