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Biology 319 : Cell & Molecular Biology, Fall, 2004

Instructor and Lab Coordinator: Dr. Paul Wanda
Classroom: SL1105
Office: SL 3318
SL - (618)650-2336

email (best way to contact me):
URL (My Web Page):
Office Hours : . Office Hours will usually be : Monday & Wednesday 1:30pm - 2:30pm or by appointment
Any changes will be posted in the 'Weekly Objectives' link (click on link )

Graduate Teaching Assistants: Ben Hilby, Jeffrey Simmons, Sufurah Khan, and Marilyn Caldwell

Text: Essential Cell Biology, by Alberts, et al

Course/Learning Objectives:

To understand the problems in cell biology

To understand the molecular basis of cell biology

To gain laboratory skills in cellular & molecular biology

Course Description:

This course deals primarily with 'eukaryotic cell biology at the molecular level' such as protein-protein, protein-nucleic acid, and protein-lipid interactions , the synthesis and expression of the genome and communication between cells. This is cell biology at the molecular level.

Although many of you are familar with some experimental techniques, there are some applications that are unique to cell & molecular biology and perhaps not in your technical toolkit, so we will deal with learning objectives that address competence in the use of biotechnology, instrumentation, and research methods in cell & molecular biology. Additional learning objectives will introduce challenges to your analytical and intuitive skills by analyzing figures and data in the laboratory in small group interactions. Lastly, a learning objective addressing introduction to quantitative skills will be covered in several laboratory topics . A brief outline for the course is listed below. Syllabus details will be posted on our Web site on a weekly basis. We will not be locked into a rigid time frame for a topic so we will sometimes gauge our progress using the syllabus as a guide. Sometimes we may have to skip or spend extra time on a topic.We will have a couple of 'exam review days'instead of lecture - this way , we have the room and time provided ( otherwise, logistics are tricky). Reading assignments are highly recommended ; this is such a well written book. If there is outside reading it will be provided by either posting material on reserve at the library or as class handouts or in our Biol. 319 showcase (outside of lab 3215). Although we will primarily cover animal cell biology, plant, bacterial,and viral systems will also be explored as important examples. We will occasionally work out problems at the end of the chapter or from other sources. We will also see 4 or 5 films to get a visual of a lecture topic.Lectures will focus on mechanisms- how things work.

Vocabulary: Click on link for Biol. 319 on our Website.

I strongly recommend ongoing construction of a vocabulary deck if you are unfamilar with terms used in lecture. The old-fashioned 'Flash Card' concept is time honored!

It is assumed that the fundamentals of animal and plant biology are a part of your background ( the first two core courses in our biology curriculum). Organic chemistry (Chemistry 241A), past or current enrollment , is also required.

Course Policies:

School closing(s): Exams that are postponed due to the University closure (bad weather) or a science building evacuation will be rescheduled for the next class meeting.

Assigned number: Each student will receive an assigned number to use for identification for any (e.g. optional final) posted scores on the Web Site .

Please refrain from munching on noisy snacks during lecture. Also, please do not bring children to class. Emergency situations will happen and we can deal with these on a case by case basis if discussed prior to lecture.

Incompletes: Incomplete grades will be given only to students unable to complete the required course work because of a verifiable crisis and at the discretion of the instructor. The College of Arts and Sciences has an approved contract form dealing with incompletes; see me for information if this applies to your situation. Incompletes will NOT be given for bad grades.

Exam issuance and make-ups: No exam will be handed out to a student after the first person hands in a exam. No extra time will be given to any student coming late to the exam. Please remove caps or hats during the exam.

Each student may makeup one exam if you take the makeup exam within one lecture of the scheduled exam date by calling my office (618-650-2336) or email ( BEFORE the scheduled exam. If you had an emergency that prevents this, please discuss this with Dr. Wanda as soon as possible. Make-up exams usually have different questions and primarily be in an essay format. There will be NO make -up exam for the optional final exam or quizzes. The final exam does not represent a 'make-up' exam for a regular missed exam (score = zero) .

Exam seating: The instructor/TA reserves the right to relocate students during a test.

Attendance: Class attendance in lecture is required. Attendance will be taken during the first week of class. Students who do not attend the first week of class will be removed from the class list. Since the exams cover a big portion of lecture material and class handouts, the easiest way to earn a good grade is to come to class and to have a good set of lecture notes. The textbook will serve both as a reference source for the material covered in lecture and as a direct source of exam questions. I can offer study suggestions but if you do not apply yourself to the material, chances of success are slim. Study at least 1-2 hours /day. The instructor assumes that all students are attending class regularly , doing the assigned reading , using the Web site and that they are therefore fully informed of any announcements made in class or posted on the course Web site).Your continued enrollment in this course indicates that you have read and understood this syllabus by signing the last page of the syllabus (which has your assigned number) and returning it to Dr. Wanda during the first week of class.

Withdrawals: If you stop attending class and taking tests without discussing it with Dr. Wanda, you will get a UW. The final day to withdraw from class without the permission of your advisor and the instructor is October 29, 2004. Students who withdraw after that time may receive a WP or WF based on work to date (the grade percentage includes any missed test BEFORE the withdrawal) and must have the permission of the instructor. The last day to withdraw from a class or from school with permission of advisor and instructor is November 19, 2004.

Lecture Topics: General View of Topics

Week 1 - Syllabus; Weak interactions ; Allosterism ; Biomolecules ;Read Chapter 2 for Week 1.

Week 2 - Proteins; Enzymes to Prions, Read Chapters 3&4 ;

Week 3 - NO CLASS on Monday (Labor Day); Wednesday -:Brain Eaters; Quiz on Friday (9/10/04).

Weeks 4-6 - DNA structure, replication, nature of our genome, microarray technology, Human Genome Project. Films: DNA : Secret of Life and Cracking the Code; Read Chapters 5& 6. RNA -mRNA, tRNA, and rRNA. Classic film: Protein synthesis. Wednesday (9/15/04) will be exam review day. EXAM #1 on Friday, (9/17/04)

Weeks 7-9 - RNA processing and splicing details; read chapter 7. Quiz on Friday (10/1/04). Lipids, membrane proteins , membrane structure, and transport mechanisms; Read Chapters 11 & 12,. On Wednesday, October 20, 2004, we will have Exam #2 Review Day. EXAM #2 - on Friday 10/22/04 (covers material since exam #1).

Weeks 10- 13 - Endoplasmic reticulum and Golgi roles in protein sorting and glycosylation; lysosomes;cell communication. Read Chapters 15 7 16. On Friday, November 12, 2004, we will have Exam #3 Review Day. Exam #3 will be on Monday, 11/15/04 on material covered since exam #2).

Week 14 -15 -Oncogenes , genetic basis of cancer; cell cycle and cell death. Film: Curing Cancer. read Chapters 18 & 21. Quiz on Wednesday, December 8, 2004. Review for optional comprehensive final will be on Friday, December 10, 2004.

Finals week - Comprehensive Optional Final Exam ( 100 points ; multiple choice & short answer format) ; You can elect to take this exam during the regularly scheduled final exam time only if you wish to erase your lowest exam score; it will not count as your lowest exam score ; there is NO make-up for the final exam. Note : this exam will substitute for your lowest exam score (one exam only and NOT for a missed exam) .

* Please note that considerable details on topics and reading will be available in the 'Weekly Objectives' link posted on the Web site.

Important Dates:
Quiz #1 (25 points) - 9/10/04
Exam #1 (100 points) - 9/17/04
Quiz #2 (25 points) - 10/1/04
Exam #2 (100 points) - 10/22/04
Exam #3 ( 100 points) - 11/15/04
Quiz #3 (25 points) - 12/8/04
Optional Comprehensive Final (100 points) - Thursday, December 16, 2004 (10:00 - 11:40am) .
TOTAL POSSIBLE POINTS = 520 (375 lecture +145 lab)

Exam Format and Final Grades:

Exam and quiz questions will include multiple choice and an assortment of short essay, short answer and problem solving formats . We recycle our Scantron (provided). Letter grades will be based as follows: 90 - 100%, A; 80- 89% ,B; 70- 79% ,C; 60- 69%, D; less than 60%, F. **final exam score; substitutes only for lowest regular exam score; Our class has a lot of students; exams will generally take three days to grade but recording grades and preparing the 'return' package is time-consuming so all together this will mean that exams will usually be returned in one week's time.
Your signiture on the last enclosed page will signify your acknowledgment of the policies in this syllabus. Be sure to record the assigned number in your notebook or elsewhere. THANK YOU!
Assigned #* Scores
9 80.5
11 45
12 67.5
14 60
16 55.5
18 91
21 53
22 75.5
24 69
27 71
29 60
30 86
33 44
37 81
38 93
39 66.5
40 58.5
46 78
47 59
49 56
54 87.5
55 75
59 77
60 97
62 90
63 72
70 92.5
73 53.5
74 44
75 52
77 32
78 70
81 57.5
86 68.5
88 81
89 45.5
97 74
98 62.5
99 37.5
102 66
107 57
109 65
110 59
111 77
115 58
125 82
126 45
127 44
128 70
134 94
135 76.5
139 42.5
164 70.5
162 51
149 58.5
150 59.5
152 71.5
156 72.5
158 66
159 68
166 69
168 50