Biology 205 : Human Diseases, Summer , 2005

Instructor: Dr. Paul Wanda
Classroom: SL 1105
Office: SL 3318
SL - (618)650-2336

URL (Web Page):
Office Hours : Any changes will be posted in the 'Weekly Objectives'. Usual Office Hours will be : M & R at 9:00-9:50 am

or by appointment

Text: Human Diseases: A Systemic Approach by Mulvihill, et al

Course Description:

Welcome to an intricate subject - Human Diseases. In this course, you will gain an understanding of the basis of many human diseases and details on several selected disease topics, most of which are in the news everyday or perhaps afflicting a relative , yourself or a close friend. Lecture material will explain the basis behind the diseases and their current status. Exam material will come from lectures ,the reading assisgnments,handouts, and films therefore your attendance and note taking will be essential for success in this course. 'Weekly Objectives' (available on the Web page), will include weekly lecture goals, any changes in the syllabus, announcements. A vocabulary list will be posted our our Web site link, "Vocabulary"or handed out in class . The reading assignment (particular pages in a chapter) will be detailed in the "Weekly Objectives".

Course Objectives:

One of the primary course objectives is for you, the student, to be able to comprehend future newspaper/magazine articles on human diseases (especially since your mate or relatives will now consider you an expert in human diseases!).

A second course objective is to gain an understanding of the underlying causes of human diseases and how potential therapies work.


A fact of life, much to the chagrin of many students, is that a new vocabulary, often appearing to border on a new language, faces us when we encroach on the fringes of the medical profession. I have found no miracle to avoid that fact of life in this course. It is very important to know how each vocabulary word is used in the context of human disease. I strongly recommend ongoing construction of a vocabulary deck on index cards or a vocabulary notebook. The old-fashioned 'Flash Card' concept is time honored! Lecture Notes and Study Skills: Please see me as soon as possible if you need help in this course! SUGGESTION: Review lecture notes soon after the lecture and perhaps start a second 'study notebook' . Compare notes with a classmate. Make an outline of the topic and supplement it with text information and drawings. Study with a classmate and quiz each other.


In this era, the student is dealt an injustice by attempting to provide an adequate understanding of human disease without teaching how cells work in relation to disease. We will

focus on a select number of carefully chosen human diseases and, to some extent, exploit these as a format for presenting and understanding the cellular biology ( ie., what's wrong with our system(s )) relevant to those diseases. During week 1 , you will get a 'primer ' on biological molecules and human cell function.

The first part of the course deals with infectious diseases caused by bacteria and viruses. This logically follows our study of biomolecules and cells. The next topic will deal with our immune and non-immune defense systems. Immunological disorders and HIV and its connection to AIDS will be examined. This will be followed by Genetic Diseases . Genetically inherited diseases give us an opportunity to lay the groundwork for the molecular basis of inheritance. The heritable disease sickle cell anemia will be used as a working model to develop the entire picture of how a single mistake in a single gene can lead to a debilitating disease (however, afflicted individuals have resistance to malaria - a survival enhancer). This system will also help in understanding how the disease is passed from one generation to the next, and why the pattern of inheritance that is observed makes sense. Sex-linked diseases such as color-blindness and baldness will be examined . We will also examine stem cell therapy, gene therapy, and the latest in the use of gene arrays (new DNA/RNA) applications to health. Cancer - the genetic basis - will be an important topic reviewed in this section.

This will be followed by what's known as physiological diseases. These are less precisely defined and generally more poorly understood than the diseases arising from known genetic defects. In many cases the diseases have a genetic aspect, in that the tendency to develop the disease may run in families and may be inherited. The physiological diseases may involve interactions between several systems in the body and often arise due to external or environmental factors. Many of these appear later in life, i.e., hypertension and diabetes and corresponding therapies will be examined in detail.

We will end by covering certain selected neurological disorders. We'll include Alzheimer's ,Huntington's, Parkinson's diseases and Multiple Sclerosis.

In summary, the subject matter itself commands its own high level of interest and it is my expectation that you have a keen interest in gaining a better understanding of human disease.

Please refrain from munching on noisy snacks during lecture. Also, please do not bring children to class. However if emergency situations happen we can deal withthese on a case by case basis if discussed prior to lecture. When we have a EXAM scheduled, it may be given at the beginning of our class period, so BE ON TIME! If students skip lecture after the exam, then exams will be administered near the end of class time. An exam will not be given to anyone arriving after the first exam is turned in (usually occurs after 10 minutes or so).

RULES FOR EXAMS: Sit with at least one seat apart; if you are wearing a cap, place the bill of the cap backwards ( like a 'catcher'); don't ask to leave the room;turn off cell phones; no whispering or other communication except with Dr. Wanda;put notes, etc, away inside something so that no one can see them; cover your Scantron sheet while taking the exam; no electronic devices of any kind may be used during the exam. The instructor reserves the right to move students during the exam . Cheating will be penalized as permitted by the University.


Week 1 - Syllabus; Biomolecules; Infectious agents; Emerging Diseases (SARS, Mad Cow, HIV, West Nile) Read chapter 3; Film and handout.

Week 2 Host defenses; Vaccines; Immune system disorders, including allergies .Supplemented by films and handouts. Read Chapter 2.

Week 3: Introduction to DNA and genes ( Read Chapter 5) and their relation to Genetic Diseases; The Genetic Basis of Cancer; Supplemented by films and handouts.

Week 4: Diseases of the Cardiovascular System; Hypertension and drug therapies; Read chapters 7,8, & 9; Endocrine System with a focus on Diabetes ( Read Chapter 14 ; handout) . b>


Week 5: Neurological Disorders; Alzheimer's Disease; Parkinson's & Huntington's Diseases; Film: 'The Frozen Addict' ; Read chapters 4 & 16. -


* Please note that details on topics and reading , or any changes to the syllabus will be available in the 'Weekly Objectives'link on our Web site.

Important Dates:(Exam dates may change)

Exam #1 - (5/31/05) 50 points
Exam #2 - (6/6/05) 50 points
Exam #3 -(6/16/05) 50 points

Exam #4 - (6/23/05) 50 points
Extra Credit Due - (6/23/05)

No Final Comprehensive Exam).
Exam Format and Final Grades, out of 200 total points.Extra credit is a BONUS.

No exam grades will be dropped. The exams have a Scantron component (multiple choice) and short answer/essay formats. We will keep the original answer sheet since it will be reused for each exam, however a copy of your answer sheet with a Scantron key and the exam will be returned to you. BOTH the Scantron answer sheet and the original examMUST be turned in after an exam is completed in order to receive a grade .Note, however, only answers on the Scantron sheet will be scored. Exam questions will have a multiple choice format . If videos are shown in class, they are considered part of the lecture material covered on exams - TAKE NOTES!
Letter grades will be based as follows: 90 - 100%, A; 78- 89% ,B; 63- 77% ,C; 52- 62%, D; less than 52%, F. This scale applies final grades. Graded exams will usually be returned at the next scheduled class meetings. Each student may make-up only one examIF you do so within two lectures from the scheduled exam date .You are responsible for: FIRST calling my office (618)650-2336 or emailing me BEFORE the scheduled exam. If you have endured an emergency that prevents you from making up the exam within the prescribed time, please discuss this with Dr. Wanda as soon as possible. Make -up exams will have different exam format (mostly essays). DSS - students have the responsibility of providing exam release papers PRIOR to the exam. These students must take the exam at the scheduled date and time, and then return to class for the remainder of the lecture, if the exam is given at the beginning of lecture.

Students who do not attend the first two lectures will be removed from the class list. If you stop attending class and taking the exams without discussing it with Dr. Wanda, you will get a UW. Withdraw policy and dates can be found in the Summer Announcements. For any WP/WF withdrawal, the grade percentage will include any missed exam that occurred BEFORE the withdrawal . Incomplete grades are NOT given for poor grades ; incompletes must conform to University policy; have a major verifiable familial or medical emergency, and are at the discretion of the instructor. Incompletes are not an 'automatic'.

ATTENDANCE: Class attendance is required. Since our exams cover mostly lecture material, which may not be in the text, plus material in videos and handouts, a good set of notes is essential. The easiest way to have a good set of lecture notes is to attend class and to have good note-taking skills. The lectures will cover material that is not in the textbook; we will not cover all the material in the textbook. It is your responsibility to attend class, to obtain notes from other students if you need them, and to obtain copies of handouts if you cannot attend class, and to inform yourself of any announcements made in class. The instructor assumes that all students are attending class regularly and on time and that they are therefore fully aware of any announcements made in class.

EXTRA CREDIT: You can earn 20 'extra' points by handing in ten newspaper clippings on HUMAN DISEASE topics on (6/23/05) . No early /late turn-ins. You MUST highlight the significant sections of the article, AFFIX it to sturdy paper or put inside a sheet protector, and INCLUDE the newspaper source and date (one magazine article will be accepted but internet articles will NOT be accepted). You MUST include your name and assigned number on the cover page for full credit. Only two articles per specific topic and they MUST be related to HUMAN diseases. The extra credit will not be returned, however scores will be posted on our syllabus link, using your assigned number. If you did not receive full credit then it is because you did not follow directions. Again, ONLY 10 articles ; must be on HUMAN DISEASE (not just a mention of a disease with no 'BIOLOGY' discussed!!!!!!!; -2 pt deduction for each 'extra' article; exceedingly brief articles are not counted!!!


EXTRA CREDIT INFORMATION: CREDIT was NOT given for articles on cattle, horses, soybeans, celebrities diagnosed with a disease, autistic learning disabilities, diet articles, vitamin articles, disease awareness day, most health screenings, cancer stats or other articles that just had a single mention of a disease, articles one paragraph long with one science word highlighted; we had numerous examples what was deemed an acceptible article.

4th Exam score is listed below; later the Extra Credit project grades and ethical E.C will be listed as + scores; #1=34.5; +4,+14 ; #2=28.5; +3,+20 ; #3=29; +3, +16 ; #4=39; +6, +20 ; #6=22 ; +4, +18 ; #7=49; +5, +18 ; #8=23.5; +12 ; #10=40; +20 ; #11=38.5; +6, +18; #12=44.5; +5, +18 ; #13=32; +6, +20 ; #14=39; +3, +16; #15=24; +5, +20 ; #16=25.5; +3, +18 ; #17=41; +5, +20 ; #18=25; +16; #19=22.5; +5, +4; #20=19; +4, +6; #22=32.5; +5, +16. .