Chin-Chuan Wei, Ph.D.

My main research interests lie in understanding the molecular basis of protein function. Of particular interests are studies of metalloenzymes structure/function, protein electron transfer, protein-protein interactions, and receptor-ligand interactions that are involved in biological signal transduction. My current projects aim to understand the mechanism of nitric oxide (NO) synthesis by human and plant nitric oxide synthases (NOSs) and reactive oxygen species (ROS) production by non-phagocyte NADPH oxidase enzymes (NOX). NOS and NOX play important roles in the control of fundamental physiologic processes, including vascular tone, platelet function, neuron signaling, mitosis, apotosis, and cell migration. Understanding how auxiliary cellular components and factors interact with enzymes to control their biochemical reactions presents exciting challenges.

Research interests include: