Christopher W. Theodorakis
Department of Biological Sciences and
Environmental Sciences Program
My research interests are in evolutionary toxicology, molecular and genetic toxicology, aquatic ecotoxicology, population genetics, biomarker research, oxidative stress, and endocrine disruption.
Specific research interests and past projects include:
· Effects of chemicals, ionizing radiation, and UV radiation on DNA damage in aquatic organisms.
· Effects of chemicals, radiation, and human land use on population genetic diversity and evolution of resistance in fish and amphibians.
· Application of integrated suites of multiple biomarkers to biomonitoring and risk assessment
· Molecular mechanisms of genetic adaptation to pollution and radiation
· Relationship between DNA damage and fitness-related parameters (growth, survival, reproduction, development) in fish and frogs.
· Toxicokinetics of perchlorate in fish and frogs.
· Effects of thyroid-disrupting compounds on thyroid hormone status and histopathology, growth, development, reproduction, and gene expression in fish and frogs.
· Effects of thyroid endocrine disruption on DNA damage, oxidative stress, and developmental effects induced by chemicals and UV radiation
· Relationships between DNA damage and molecular effects of pollution and higher-level (community, ecosystem) effects of pollution.
· Toxicity of high explosive compounds to fish and frogs.
· Combinative toxicity of fungal toxins (mycotoxins) to fish.
· Distrubution of blue-green bacterial toxins (microcystins) in fresh waters.
· Effects of multiple stressors and combinative toxicity on fish and amphibians.
Current research projects include:
· Conservation genetics of gopher frogs and gopher tortoises impacted by chemical pollution and habitat modification on military bases. Click here for more information.
· Toxicity of metal oxide nanoparticles in fathead minnows and African clawed frogs. Click here for more information.
Other research interests
· Estrogen disruption in fish, and effect of estrogen disruption on DNA damage.
· Toxicity and endocrine disruption of pharmaceuticals in fish, amphibians, and aquatic invertebrates.
· Ecogenomics, ecotoxicogenomics and proteomics
· Pollutant-induced apoptosis, relevance of apoptosis to fitness-related and ecologically relevant endpoints, and application of markers of apoptosis for biomonitoring and ecological risk assessment
· Effects of herbicides on amphibians
· Effects of landscape structure and landuse on biomarker expression, fish community structure, and fish and amphibian population genetics.
· Interrelationships between DNA damage and other physiological responses such as bioenergetics, immunotoxicity, and neurotoxicity.
· Effects of microcystins on fish alone and in combination with other chemicals.
· Effects of climate change on toxicological responses, population and community responses, and population genetics of fish and amphibians.
· Effects of climate change, landscape, and landuse on water quality and concentrations of microcystins (blue-green algal toxins).
Current courses taught
· Environmental Risk Assessment (more info…)
· Environmental Health and Waste Management (more info…)
· Introductory Animal Biology for Majors (more info…)
· Introductory Biology for Non-Majors (more info…)
· Conservation Genetics
· Aquatic Ecotoxicology
Previous courses taught
· Genetic toxicology (syllabus)
· Molecular toxicology (syllabus)
· Aquatic toxicology (syllabus)
· Principles of Toxicology II
· Introductory biology
· Human anatomy
· Comparative anatomy
Southern Illinois University Edwardsville