| Organization Name | Description | Organization Type | Campus Box | Adviser Campus Box Phone Number |
| Aerospace Club | Supports cadets of Air Force ROTC in their pursuit of becoming future Air Force Officers. Open to any student and faculty. | Special Interest | 1168 | Anthony Patino, 1LT Box 1048 618-650-5903 |
| Alpha Phi Omega | Service Fraternity. Members must fulfill financial, service, scholarship, and attendance obligations. | Special Interest | 1168 | Brian Hinterscher |
| American Cancer Society Colleges Against Cancer | Purpose of reducing cancer incidence and death and measurably improving quality of life for cancer patients and survivors. | Special Interest | 1168 | Kay Gaehle Box 1066 618-650-3976 |
| American Red Cross Club | Provide students and faculty with an opportunity to further the mission of the Red Cross. | Special Interest | 1168 | Gerald Schlemer Box 1129 618-650-2871 |
| Circle K Club | This is an international service organization. | Special Interest | 1168 | Nancy Ellington |
| College Democrats | Provide opportunity to stimulate in the SIUE community an active interest in governmental affairs, increase the efficiency of popular government, to foster and perpetuate the ideals and principles of the Democratic Party. | Special Interest | 1168 | Nicholas Guehlstorf |
| College Republicans | Develop political skills and leadership abilities among Republican students as preparation for future service by them to the party, the community, and the country. | Special Interest | 1168 | Ray Darr |
| Disney College Program Alumni Association | To promote the Disney College Program, provide support and networking opportunities to current program participants and Alumni, to prepare future participants for the program and to provide support to the community though volunteer and community service projects. | Special Interest | 1168 | Connie Dake |
| Game Development Group | Member will practice their skills and meet others with a similar interest, specifically video game development. The group will work together to procurea final result that everyone will be proud of. | Special Interest | 1168 | Dennis Bouvier |
| Gay-Straight Alliance | Purpose is to provide an atmosphere of support for gay and lesbian students. Open to all students. | Special Interest | 1168 | Robyn Berkley |
| Gospel Choir | Promotes cultural awareness of Afro-American gospel music. Open to any student in good standing. | Special Interest | 1168 | Lydia Jackson |
| Making Waves | Purpose is to educate students in regards to women's issues, studies, and activities/programs. Open to all with a 2.0 GPA. | Special Interest | 1168 | Carly Hayden Foster |
| Metro East Community Chorus and Orchestra (MECCO) | Opportunities for professional development, create inspiring music for the community and to raise awareness and financial support for the National Breast Cancer Foundation, Inc. | Special Interest | 1168 | Joel Knapp |
| Purpose is to make the university experience for students with disabilities easier and more accessible. Open to all students. | Special Interest | 1611 | Jim Boyle | |
| One Mic Poetry | The purpose of One Mic Poetry is to enrich the lives of all men and women through the vessel of spoken word. | Special Interest | 1168 | Adrian Matejka |
| Percussion Club of SIUE | To reach those interested in percussion. | Special Interest | 1168 | Daniel Smithiger Box 1771 618-650-3913 |
| PREMIERe Models | The purpose of the organization is to provide training, experience, and modeling opportunities to those who share interest in fashion, modeling, and/or photography. | Special Interest | 1168 | Kelley Brooks Box 1600 618-650-2628 |
| Raise Your Voice | Raise Your Voice works to promote civic engagement i.e. actions that educate people of the social, political, and economic issues. | Special Interest | 1168 | Suzanne Kutterer-Siburt |
| RAM (Retention of African American Men) Association | To foster a supportive environment with workshops, events, mentors, and academics for African-American men. | Special Interest | 1168 | Earleen Patterson |
| To better understand and promote sustainability. | Special Interest | 1168 | Valerie Vogrin | |
| Student-Athlete Advisory Committee | Support the mission of Intercollegiate Athletics at SIUE. | Special Interest | 1168 | Lindsey Schmidt Box 1129 618-650-3925 |
| Students Today, Alumni Tomorrow (STAT) | STAT will enhance the personal, academic and professional development of students of SIUE - past, present and future - through establishing and maintaining of mutually beneficial relationship with SIUE alumni. | Special Interest | 1168 | Katie Bennett |
| Student Union for Racial Equality (SURE) | The purpose of the Student Union for Racial Equality is to provide all interested individuals with the opportunity to ask questions, eliminate steorotypes, and take organized steps towards improving the perspectives of the greater society. This organization will unite individuals of all races to creatively and concurrently inspire the campus community and outlying individuals to open their minds to racial harmony. | Special Interest | Renee Fussell | |
| Tactics Club | Enhances members' minds with strategic, military, and historic knowledge through practical exercises. Open to all students. | Special Interest | 1168 | Michael Porch |
| US Army ROTC Cadet Club | Purpose is to work toward full student participation in all aspects of the Army ROTC and Cadet Club programs; to improve the ROTC program and themselves. | Special Interest | 1352 | James Gottschling |
| Veterans Student Association | To provide information and support veteran’s affairs for all students and members of the community. | Special Interest | 1168 | Matthew Cerminn |
| Purpose is to enhance student life on campus, to help equip students for a future in radio. Must pass a "Board Test" and have 2.0 GPA. | Special Interest | 1775 | Musonda Kapatamoyo |