Associate Professor of Pharmaceutical Sciences
Phone: 618-650-5168
Fax: 618-650-5145
E-mail: rworthi@siue.edu
Personal webpage: http://ronw.me
Teaching: Pharmacogenomics, Molecular Biology, Pharmaceutical Biotechnology
A.B., 1974, Washington University in St. Louis
Ph.D., 1982, Washington University in St. Louis
Postdoctoral, 1982-1984, Washington University in St. Louis & Texas Tech Health
Sciences Center
Research:Human genetic variation related to disease risk and drug response
Harvard Personal Genomes Project
Annotation of rare human genomic variants with large effect
Bioinformatics, computational biology
Publications:
1. Carroll, R. C. et al. Post interventional cardiology urinary thromboxane correlates with PlateletMapping detected aspirin resistance. Thromb Res 125, e118-22 (2010).
2. Bischoff, K. M., Liu, S., Leathers, T. D., Worthington, R. E. & Rich, J. O. Modeling bacterial contamination of fuel ethanol fermentation. Biotechnol Bioeng 103, 117-122 (2009).
3. Pharr, P. N., Hofbauer, A., Worthington, R. E. & Longmore, G. D. Residual erythroid progenitors in W/W mice respond to erythropoietin in the absence of steel factor signals. Int J Hematol 72, 178-185 (2000).
4. Rubinstein, E., Boucheix, C., Worthington, R. E. & Carroll, R. C. Anti-platelet antibody interactions with Fc gamma receptor. Semin Thromb Hemost 21, 10-22 (1995).
5. Ryan, U. S. & Worthington, R. E. Cell-cell contact mechanisms. Curr Opin Immunol 4, 33-37 (1992).
6. Boucheix, C. et al. Molecular cloning of the CD9 antigen. A new family of cell surface proteins. J Biol Chem 266, 117-122 (1991).
7. Worthington, R. E., Carroll, R. C. & Boucheix, C. Platelet activation by CD9 monoclonal antibodies is mediated by the Fc gamma II receptor. Br J Haematol 74, 216-222 (1990).
8. Carroll, R. C., Rubinstein, E., Worthington, R. E. & Boucheix, C. Extensive C1q-complement initiated lysis of human platelets by IgG subclass murine monoclonal antibodies to the CD9 antigen. Thromb Res 59, 831-839 (1990).
9. Carroll, R. C., Worthington, R. E. & Boucheix, C. Stimulus-response coupling in human platelets activated by monoclonal antibodies to the CD9 antigen, a 24 kDa surface-membrane glycoprotein. Biochem J 266, 527-535 (1990).
10. Worthington, R. E. Calcium response to erythropoietin in erythroleukemia cells. Exp Cell Res 184, 250-255 (1989).
11. Worthington, R. E., Bossie-Codreanu, J. & Van Zant, G. Quantitation of erythroid differentiation in vitro using a sensitive colorimetric assay for hemoglobin. Exp Hematol 15, 85-92 (1987).
12. Worthington, R. E. & Van Zant, G. Resistance to erythroleukemia in immunodeficient xid- CBA/N mice with susceptibility after immune stimulation. Cancer Res 46, 3441-3444 (1986).
13. Worthington, R. E., Nakeff, A. & Micko, S. Flow cytometric analysis of megakaryocyte differentiation. Cytometry 5, 501-508 (1984).
14. Worthington, R. E. & Fuller, G. C. Dibutyryl cyclic guanosine monophosphate elevates bovine endothelial cell thromboxane production without affecting prostacyclin metabolism. Thromb Res 33, 163-175 (1984).
15. Worthington, R. E. & Nakeff, A. Aspirin inhibits rat megakaryocyte thromboxane synthesis. Prostaglandins 23, 841-853 (1982).
16. Worthington, R. E. & Nakeff, A. Thromboxane synthesis in megakaryocytes isolated by centrifugal elutriation. Blood 58, 175-178 (1981).
17. Levine, S. D., Levine, R. D., Worthington, R. E. & Hays, R. M. Selective inhibition of osmotic water flow by general anesthetics to toad urinary bladder. J Clin Invest 58, 980-988 (1976).
18. Levine, S. D. & Worthington, R. E. Amide transport channels across toad urinary bladder. J Membr Biol 26, 91-107 (1976).
Grants
SIUE New Directions grant, "Participation in the Personal Genomes Project," 2011
National Science Foundation (NSF0538739) "Studies to prevent antibiotic resistance in ethanol fermentation", 2006 to 2009
National Cancer Institute, NIH, 5R23CA042902-04, “erythropoiesis and resistance to leukemia”, 1986-1989
