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School of Pharmacy
School of Pharmacy
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Associate Professor of Pharmaceutical Sciences
Phone: 618-650-5168
Fax: 618-650-5145
E-mail: rworthi@siue.edu

Personal webpage: http://ronw.me

Ron Worthington


Teaching: Pharmacogenomics, Molecular Biology, Pharmaceutical Biotechnology
AB, 1974, Washington University in St. Louis
PhD, 1982, Washington University in St. Louis
Postdoctoral, 1982-1984, Washington University in St. Louis & Texas Tech Health Sciences Center


Recognized by the Office of the Provost as a SIUE Teacher-Scholar

Research
Human genetic variation related to disease risk and drug response

  • Harvard Personal Genomes Project
  • Annotation of rare human genomic variants with large effect
  • Bioinformatics, computational biology

Publications

Carroll, R. C. et al. Post interventional cardiology urinary thromboxane correlates with PlateletMapping detected aspirin resistance. Thromb Res 125, e118-22 (2010).

Bischoff, K. M., Liu, S., Leathers, T. D., Worthington, R. E. & Rich, J. O. Modeling bacterial contamination of fuel ethanol fermentation. Biotechnol Bioeng 103, 117-122 (2009).

Pharr, P. N., Hofbauer, A., Worthington, R. E. & Longmore, G. D. Residual erythroid progenitors in W/W mice respond to erythropoietin in the absence of steel factor signals. Int J Hematol 72, 178-185 (2000).

Rubinstein, E., Boucheix, C., Worthington, R. E. & Carroll, R. C. Anti-platelet antibody interactions with Fc gamma receptor. Semin Thromb Hemost 21, 10-22 (1995).

Ryan, U. S. & Worthington, R. E. Cell-cell contact mechanisms. Curr Opin Immunol 4, 33-37 (1992).

Boucheix, C. et al. Molecular cloning of the CD9 antigen. A new family of cell surface proteins. J Biol Chem 266, 117-122 (1991).

Worthington, R. E., Carroll, R. C. & Boucheix, C. Platelet activation by CD9 monoclonal antibodies is mediated by the Fc gamma II receptor. Br J Haematol 74, 216-222 (1990).

Carroll, R. C., Rubinstein, E., Worthington, R. E. & Boucheix, C. Extensive C1q-complement initiated lysis of human platelets by IgG subclass murine monoclonal antibodies to the CD9 antigen. Thromb Res 59, 831-839 (1990).

Carroll, R. C., Worthington, R. E. & Boucheix, C. Stimulus-response coupling in human platelets activated by monoclonal antibodies to the CD9 antigen, a 24 kDa surface-membrane glycoprotein. Biochem J 266, 527-535 (1990).

Worthington, R. E. Calcium response to erythropoietin in erythroleukemia cells. Exp Cell Res 184, 250-255 (1989).

Worthington, R. E., Bossie-Codreanu, J. & Van Zant, G. Quantitation of erythroid differentiation in vitro using a sensitive colorimetric assay for hemoglobin. Exp Hematol 15, 85-92 (1987).

Worthington, R. E. & Van Zant, G. Resistance to erythroleukemia in immunodeficient xid- CBA/N mice with susceptibility after immune stimulation. Cancer Res 46, 3441-3444 (1986).

Worthington, R. E., Nakeff, A. & Micko, S. Flow cytometric analysis of megakaryocyte differentiation. Cytometry 5, 501-508 (1984).

Worthington, R. E. & Fuller, G. C. Dibutyryl cyclic guanosine monophosphate elevates bovine endothelial cell thromboxane production without affecting prostacyclin metabolism. Thromb Res 33, 163-175 (1984).

Worthington, R. E. & Nakeff, A. Aspirin inhibits rat megakaryocyte thromboxane synthesis. Prostaglandins 23, 841-853 (1982).

Worthington, R. E. & Nakeff, A. Thromboxane synthesis in megakaryocytes isolated by centrifugal elutriation. Blood 58, 175-178 (1981).

Levine, S. D., Levine, R. D., Worthington, R. E. & Hays, R. M. Selective inhibition of osmotic water flow by general anesthetics to toad urinary bladder. J Clin Invest 58, 980-988 (1976).

Levine, S. D. & Worthington, R. E. Amide transport channels across toad urinary bladder. J Membr Biol 26, 91-107 (1976).

Grants

  • SIUE New Directions grant, "Participation in the Personal Genomes Project," 2011
  • National Science Foundation (NSF0538739) "Studies to prevent antibiotic resistance in ethanol fermentation", 2006 to 2009
  • National Cancer Institute, NIH, 5R23CA042902-04, “erythropoiesis and resistance to leukemia”, 1986-1989

Honors

  • Endowed by the School of Pharmacy Class of 2012 the “Dr. R. Worthington Award of Excellence” scholarship fund
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