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Pharmac eutical Sciences News

July 24, 2012

NIH Awards Grant To SIUE'S Kwon For Diabetes Research

The National Institutes of Health (NIH) has awarded Southern Illinois University Edwardsville's Guim Kwon , Ph.D., a $429,000 grant to support her research project "Human Beta-cell Metabolism Signaling Under Chronic Nutrient Overload." Kwon is an associate professor of pharmaceutical sciences in the School of Pharmacy.

Kwon is seeking to develop new drugs for the treatment of type 2 diabetes and recognizes the significance of her research to everyday life. "Due to over eating and sedentary life style, obesity has become an epidemic in the U.S. and other developed countries around the world," Kwon explained. "The incidence of type 2 diabetes has been increasing proportionally to the rate of obesity. Our community is no exception. A new drug that can prevent, treat or reverse type 2 diabetes will have a huge impact on not only our community, but also millions of people around the world."

Kwon's family history contributed to her interest in pursuing the research. "My father has had type 2 diabetes for 30 years," Kwon said. "One of my uncles suffered blindness for six years and passed away at age 65 of type 2 diabetes. My oldest brother was diagnosed with type 2 diabetes a few years ago."

Dr. Mike Crider, chair of the Department of Pharmaceutical Sciences, reiterated the value of the research, adding, "Dr. Kwon's research in studying the relationship between obesity and diabetes is extremely important in finding new drug therapies for the treatment of type 2 diabetes. The NIH award which Dr. Kwon received will greatly aid our research efforts in the School of Pharmacy and will enhance our research competitiveness on a national level. Dr. Kwon typifies a true teacher scholar in bringing her research into the classroom."

Kwon received training to study islet biology as a postdoctoral fellow at the Washington University School of Medicine in St. Louis. She worked in the department of immunology and pathology from 1993 until 1996. She joined the SIUE School of Pharmacy in 2005.

About the National Institutes of Health (NIH): NIH, the nation's medical research agency, includes 27 Institutes and Centers and is a component of the U.S. Department of Health and Human Services. NIH is the primary federal agency conducting and supporting basic, clinical, and translational medical research, and is investigating the causes, treatments, and cures for both common and rare diseases. For more information about NIH and its programs, visit www.nih.gov

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Andrew Kamadulski was the recipient of the 2012 Sigma XI Award for the Best Graduate Poster Presentation entitled: Synthesis of Mn(II) bishydroxyphenyldipyrromethane Complexes for Use as in Vivo Peroxynitrite Reduction Catalysts. Mr. Kamadulski has been working under the direction of Dr. Bill Neumann, Assistant Professor of Pharmaceutical Sciences.

Recently accepted or published papers from Pharmaceutical Sciences are:

M. Nieto, A. Pierini, N. Singh, C. McCurdy, R. Manzo, M. R. Mazzieri. " A Theoretical Study of Antibacterial Benzenesulfonamides Fluoroquinolones (BSFQ)" Med. Chem. (Accepted).

R. Pagliero, R. Mercado, V. McCracken, M. Mazzieri, M. Nieto. Rapid and Simple Synthesis of N-Benzenesulfonyl derivatives of heterocycles and their Antimicrobial Properties. Lett. Drug Des. Discov.. (Nov. 2011) 8(9), 778-791.

Retooling Manganese(III) Porphyrin-Based Peroxynitrite
Decomposition Catalysts for Selectivity and Oral Activity: A Potential New Strategy for Treating Chronic Pain:
Smita Rausaria, Mahsa M.E. Ghaffari, Andrew J Kamadulski, Kenny Rodgers, Leesa Bryant, Zhoumou Chen, Timothy Doyle, Michael J. Shaw, Daniela Salvemini, and William L. Neumann. J. Med. Chem., Just Accepted Manuscript • DOI: 10.1021/jm201233r • Publication Date (Web): 14 Nov 2011 Downloaded from http://pubs.acs.org on November 16, 2011

Bergman, S.J.; Ferguson, M.C.; Santanello, C. Interferons as Therapeutic Agents for Infectious Diseases. Infect Dis Clin. N. Am. 2011, 25, 819-834

Schober, J.M.; Kwon, G.; Jayne, D.; Cain, J.M. Biochemical and Biophysical Research Communications (accepted)

Li, J.; Bourne, S.A.; de Villiers, M.M.; Crider, A.M.; Caira, M.R. Polymorphism of the Antitubercular Isoxyl. Crystal Growth and Design 2011, 11, 4950-4957

Three Faculty in the Department have been awarded URCA Students for the Spring 2012 Semester: Ron Worthington, Maria Kontoyianni, Mike Crider

October 2011

Andrew Kamadulski, Graduate Student, attended the ACS Meeting in St. Louis, on October 21, 2011. Andrew presented a poster on "Synthetic Studies of Dipyrromethene Ligand Systems for the Discovery of Mn(III)-Based on Peroxynitrite Reductase Catalysts". Andrew's mentor is Dr. William Neumann.

Ron Worthington was featured on Nature News. Click the link to read more: http://www.nature.com/news/2011/111005/full/478019a.html

August 2011

Tim McPherson and Patrick Fontane have published "Pharmacists' Social Authority to Transform Community Pharmacy Practice" which appeared in Innovations in pharmacy 2011, 2(2), Article 42.

http://www.pharmacy.umn.edu/innovations/prod/groups/cop/@pub/@cop/@innov/documents/article/cop_article_347125.pdf

July 2011

Bill Neumann was a co-author on a recently published paper, "Porphyrin-crosslinked block copolymer assemblies as photophysically-active nanoscopic devices", which appeared in the Journal of Materials Chemistry, 2011, 21, 8983.

Bill was also a co-author on a paper accepted for publication in the Journal of Medicinal Chemistry, "Hydrophilic Pyrazine Dyes as Exogenous Fluorescent Tracer Agents for Real-Time Point of Care Measurement of Glomerular Filtration Rate, http://pubs.acs.org/doi/abs/10.1021/jm200257k).

Maria Kontoyianni has been appointed to the University of North Carolina School of Pharmacy Alumni Association Board of Directors. The board is comprised of up to 30 alumni who represent the UNC Eshelman School of Pharmacy alumni at large.

June 2011

Radhika Devraj and Gireesh Gupchup recently published an article in Annals of Pharmacotherapy.

Identifying Aspects of Pharmacists' Attitudes and Barriers Toward Health Literacy: A Factor Analytic Study (June) Radhika Devraj and Gireesh V Gupchup Ann Pharmacother published 13 June 2011, 10.1345/aph.1P686 http://www.theannals.com/cgi/content/abstract/aph.1P686v1?papetoc

Bill Neumann is a co-author on a recently published paper,"Multicomponent Polymer Nanostructures with Ratiometric Dual-Emission pH-Sensitivity", Journal of the American Chemical Society, 2011, 133, 8534-8543.

May 2011

Distinguished Award

Dr. A. Michael Crider will be honored as a 2011 Crittenden County Distinguished Alumni Inductee in Crittenden, Kentucky.

Publication

Karin Sandoval and Ken Witt published the following article "Age and 17β-estradiol effects on blood-brain barrier tight junction and estrogen receptor proteins in ovarietomized rats". Microvascular Research 2011, 81, 198-205.

Faculty Promotion

Dr. Ken Witt has been promoted to Associate Professor of Pharmaceutical Sciences with Tenure. Dr. Witt joined the School of Pharmacy in the fall of 2005 and is involved in research dealing with potential new treatments for Alzheimer's disease.

March 2011

Pharmaceutical Sciences Faculty Receive School of Pharmacy Research Grants for 2011

Bill Kolling $833
Guim Kwon $2700
Marcelo Nieto $2700
Tim McPherson $2700
Ken Witt $2448

Pharmaceutical Sciences Faculty Receive 2011-2012 SIUE Seed Grants for Translational and Exploratory Projects (STEP)

Ken Witt "Role of Apolipoprotein E4 in regulation of somatostatin levels and neprilysin activity", $16,000

Ron Worthington, "Construction of a genetic tool to improve therapeutic protein production in yeast", $15,981

Radhika Devraj, "Relationship between Health Literacy and Chronic Kidney Disease Outcomes", $11,140

Pharmaceutical Sciences Faculty Receive 2011 SIUE New Directions Grants

Ron Worthington, $23,310
Joe Schober/Maria Kontoyianni, $9250
Marcelo Nieto, $17,211
Guim Kwon, $13,860
Mike Crider, $4195

Published

Rausaria S, Kamadulski A, Rath NP, Bryant L, Chen Z, Salvemini D, Neumann WL, Manganese (III) Complexes of Bis(hydroxyphenyl)dipyrromethenes Are Potent Orally Active Peroxynitrite Scavengers. Journal of the American Chemical Society, 2011, 133(12), 4200-4203.

February 22, 2011

Published-Dr. Karin Sandoval , Dr. Ken Witt, and Dr. Mike Crider

Sandoval, K.E.; Farr, S.A.; Banks, W.A.; Niehoff, M.L.; Morley, J.E.; Crider, A.M.; Witt, K.A. Chronic peripheral administration of somatostatin receptor subtype-4 agonist NNC 26-9100 enhances learning and memory in SAMP8 mice. European Journal of Pharmacology 2011, 654, 53-59.

February 11, 2011

Pharmacy Receives NIH Grant

The School of Pharmacy received an Academic Research Enhancement Award from the National Institutes of Health (NIH) to study cancer. The grant for $215,000 will fund a 3-year research project in the lab of Dr. Joseph Schober in the Department of Pharmaceutical Sciences. Results of the research will significantly advance understanding of the molecular basis by which cancer cells move during tumor metastasis.

March 04, 2010

Ken Witt, Ph.D., Assistant Professor of Pharmaceutical Sciences

Dr. Ken Witt received a grant in the amount of $250,000 from the National Institutes of Health to study the effect of somatostatin subtype 4 (sst4) agonists in treating Alzheimer's disease. He will investigate the use of sst4 agonists in the degradation of amyloid beta accumulation. Alzheimer's disease is associated with a loss of memory and cognitive function. These compounds may offer potential new treatment options.

William Neumann, Ph.D., Assistant Professor of Pharmaceutical Sciences

Dr. William Neumann, in collaboration with Dr. Daniela Salvemini Assistant Professor of Pharmacology at Saint Louis University, has received a grant from National Institutes of Health in the amount of $974,024. Dr. Neumann and Dr. Salvemini will investigate the use of novel compounds that are capable to destroying peroxynitrite. These new compounds offer potential new therapies for the treatment of chronic pain without the side effects that are associated with currently used drugs.

SIUE Seed Grants for Translational and Exploratory Projects (STEP)

Four faculty members from the Department of Pharmaceutical Sciences have received the following STEP awards for 2010-2011:

William Kolling, Ph.D., Associate Professor of Pharmaceutical Sciences- Stabilization of Silver Sulfadiazine Nanoparticles Synthesized via Micro emulsions" Guim Kwon, Ph.D., Assistant Professor of Pharmaceutical Sciences-"Perservation of beta-cell Mass to Prevent and/or Reverse Type 2 Diabetes" Marcelo Nieto, Ph.D., Assistant Professor of Pharmaceutical Sciences, and Karin Sandoval, Research Assistant Professor-"Design, Synthesis and Evaluation of Novel Selective Estrogen Receptor Modulators"

Published, William Neumann, Assistant Professor of Pharmaceutical Sciences

"Chlorinated Lipid Species in Activated Human Neutrophils: Lipid Metabolites of 2-Chlorohexadecanal", D.S. Anbukumar, L.S.Shornick, C.J. Albert, Melissa M. Steward, R.A. Zoeller, W.L. Neumann, and D.A. Ford, Journal of Lipid Research published online December 17, 2009. (February 24, 2010)

Installation of a JEOL ECS 400 MHz NMR Spectrometer

The installation of a new JEOL ECS 400 MHz NMR occurred in September 2009. The new NMR will greatly assist in the Department's drug design and discovery efforts. The NMR will be housed in one of the two new laboratories dedicated to drug discovery efforts.

Computational Laboratory

A new computational laboratory under the direction of Dr. Maria Kontoyianni has been set-up in UP 220. The laboratory is equipped with the following hardware and software that are essential for drug design and discovery.

Dell Precision Dual Quad Core Intel Xeon Processors X5472 (3.00GHz,2X6M L2,1600) with 32GB of memory and 750 GB drives;Discovery Studio Bundle software by Accelrys: Their full suite of modeling and simulation applications;Schrödinger software, the full spectrum of their modules;SimBiosys eHiTS docking and Lasso scaffold hopping;Gaussian for quantum mechanics;Amber for molecular dynamics;Sybyl, the total platform of computational informatics software;DepthQ HD 3D Stereoscopic Projector with NuVision 60GX-G5 Shutter Glasses and NuVision Emitter;Four NEC AccuSync 120-BK CRT Monitors for three-dimensional visualization.

Dr. Smita Rausaria Joins the Department of Pharmaceutical Sciences as a Postdoctoral Fellow

Dr. Rausaria will join the laboratory of Dr. Bill Neumann working on the design and synthesis of peroxynitrite decomposition catalysts. Dr. Rausaria is the first postdoctoral fellow in the School of Pharmacy since the inception of the program in 2005.

Dr. Rausaria received her B.Sc. (Hons.) in chemistry from the University of Delhi, India in 2002. She then moved to the Indian Institute of Technology, Delhi to pursue graduate studies. In 2004 she received a M.Sc. degree in organic chemistry (Thesis: Synthesis of aziridines and their transformations). From there she joined the group of Professor M. Ravikanth at the Indian Institute of Technology, Bombay. In 2009 she received her Ph.D. degree in inorganic chemistry (Thesis: Synthesis of Functionalized Porphyrin building blocks for the construction of novel unsymmetrical covalently linked porphyrin dyads and pentads). Dr. Rausaria is an expert in porphyrin chemistry and has joined the Neumann group in 2010 as a post-doctoral fellow. She is currently applying her expertise for the design and synthesis of metalloporphyrin peroxynitrite decomposition catalysts.

March 5, 2009

Radhika Devraj, assistant professor of pharmaceutical sciences through the Southern Illinois University Edwardsville School of Pharmacy, recently received the American Association of Colleges of Pharmacy New Investigators Program Award, sponsored by the American Foundation for Pharmaceutical Education.

An estimated 90 million Americans-nearly half the population-have limited functional literacy skills when it comes to understanding health information. Health literacy is defined as the degree to which individuals have the capacity to obtain, process, and understand basic health information and services needed to make appropriate health decisions". Thus it refers not just to reading ability but to "functional literacy", the ability to read, write, understand, and act on that understanding. Health People 2010, which is a government initiative to improve the health of the U.S. population and the Institute of Medicine (IOM) Report on health literacy, have been driving forces for closer examination of this issue.

Currently there is little mention of health literacy in pharmacy literature. Because pharmacists are the most accessible health care professionals, the study will examine Illinois pharmacists' understanding (knowledge, attitudes and barriers) of health literacy. The results of the study will be used to make targeted recommendations and offer solutions to address the barriers faced in incorporating health literacy into patient-pharmacists interactions.

The AACP is a national organization that acts as an advocate for more than 100 colleges and schools of pharmacy in the United States, which includes more than 4,000 faculty members, 46,000 students and 3,400 individuals pursuing graduate study.

March 9, 2009

Dr. Joseph Schober received a Funded University Research (FUR) award from SIUE in 2008. The award helped fund his project identifying the role of EB1 protein in melanoma cell metastasis. Cancer metastasis is a real problem in the progression of cancer. EB1 is a promising new target for treatment of cancer, specifically, a target that may lead to development of drugs that stop cancer metastasis. Dr. Schober's FUR project uses a combination of RNA interference with live-cell microscopy and in vitro models of cell migration. An abstract of their findings was presented at The American Society for Cell Biology 48th Annual meeting.

March 17, 2009

Ashley Jarrett is a P-3 student from Granite City, Illinois working under the direction of Dr. Ron Worthington, Assistant Professor of Pharmaceutical Sciences. Ashley participated in the University Research Academy at SIUE during her P-2 year. Presently, Ashley is pursuing an independent study project on techniques to clone fragments of the LDH promoter into the Pklac1 vector using restriction free cloning. This method uses PCR reactions and linear amplification to clone pieces of DNA into a vector of choice, rather than using restriction enzymes and ligation reactions.

March 31, 2009

Dr. Ron Worthington, Assistant Professor of Pharmaceutical Sciences, has recently published a paper, "Modeling bacterial contamination of fuel ethanol fermentation" which appeared in Biotechnology and Bioengineering 2008, 103(1), 117-122. Dr. Worthington's research is funded by the National Science Foundation.

April 3, 2009

Congratulations to Dr. Cathy Santanello on being selected as the Kimmel Leadership Center Adviser of the Year for 2008-2009. The award is presented "to a student organization adviser who performs responsibilities above and beyond the expectations of the adviser's role and contributes to the growth and development of student organizations." cathy is the adviser for the P2 class.

April 3, 2009

William L. Neumann, Ph.D., Assistant Professor of Pharmaceutical Sciences recently published an article, "Peroxynitrite: a strategic linchpin of opioid analgesic tolerance" which appeared in Trends in Pharmacological Sciences 2009, 30(4), 194-2002.

April 29, 2009

Radhika Devraj- published anarticle, "Health Literacy and Kidney Disease: Toward a New Line of Research" in American Journal of Kidney Diseases 2009, 53(5), 884-889. In an editorial ( American Journal of Kidney Diseases, 2009, 53 (5), 730-732) Bryan Becker, MD stated "Devraj and Gordon should be commended for their accomplishments and their stance that we should focus on health literacy. In supporting their approach, it is very likely that we will add to our scientific literature, expand our ways of caring for patients and, most important, move toward realizing the 6 amis of optimal health care as laid out by the Institute of Medicine."

The Department of Pharmaceutical Sciences received the following STEP Awards from SIUE:

Guim Kwon, "Strategies to prevent and/or reverse Type 2 diabetes", $8,990

Tim McPherson, "Effectiveness of Xanthine Analogs for the Treatment of Cystic Fibrosis", $10,500

Bill Neumann-"Function-Oriented Synthetic Studies on the Aeruginosin Family of Serine Protease Inhibitors in Search of Factor VIIa Selectivity", $15,234

Ken Witt and Karin Sandoval -"Impact of Raloxifene (Evista) on the Structure and Function of the Aging Blood Brain Barrier", $12,000

May 29, 2009

Lacey Gamblin

MALTO Medicinal Chemistry is a regional organization which holds a miniature medicinal chemistry meeting annually to afford students an opportunity to present the results of their research. The 2009 annual meeting was held at the University of Tennessee Health Sciences Center in Memphis, Tennessee on May 17-19. A total of 113 faculty, students, and postdoctoral fellows representing schools and colleges of pharmacy from the University of Houston, Texas A&M, University of Arkansas Health Sciences Center, University of Tennessee, University of Mississippi, University of Oklahoma, University of Louisiana Monroe, and Southern Illinois University Edwardsville attended the meeting.

Lacey Gamblin from Granite City, IL, was awarded the Thomas L. Lemke Poster Presentation Award for the most outstanding poster presentation. The award included a plaque and a check for 150 dollars .Lacey is currently an American Foundation for Pharmacy Education Gateway to Research Fellow. Lacey's poster presentation was entitled, "Synthesis of Thiourea Analogues as Potential Somatostatin Receptor Subtype 4 Agonists". Dr. Michael Crider, Chair of the Department of Pharmaceutical Sciences at SIUE, has served as Lacey's faculty mentor on this research project. Lacey will begin her third professional year at the SIUE School of Pharmacy in August.

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