Assistant Professor of Pharmaceutical Sciences
Phone: 618-650-5088
Fax: 618-650-5145
E-Mail: wneuman@siue.edu
Personal webpage:
Organic and Medicinal Chemistry
B.S., 1983, University of Missouri Columbia
Ph.D., 1987, University of Missouri St. Louis
Research: Medicinal Chemistry
My laboratory focuses on three main strategies for medicinal chemistry research: 1. The development of new synthetic methodologies specifically geared for the rapid generation of new medicinally active compounds. 2. The integration of multiple pharmacological modes of action within one molecular scaffold (designed synergies). 3. The generation of synthetic enzyme systems (prevention of pathology, reversal, rescue).
Areas of primary interest include: Synthetic organic, bioorganic and medicinal chemistry, with major focus areas of structure based drug design, metals and metal complexes in biological systems; biological chemistry of reactive oxygen and nitrogen species, metal-mediated cross-coupling chemistry, and synthetic methods development for the total synthesis of biologically important molecules.
Other interest areas include: The synthesis of chemical probes for the study of biological phenomena at the molecular, cellular and organism level; synthesis of functional multi-photon absorbing probes for cellular imaging, the synthesis of conditionally activated smart molecules for biomedical and defense applications; new polymer and nanostructure-based actives delivery systems.
Projects:
1. The design, synthesis and evaluation of new peroxynitrite decomposition catalysts for the attenuation and reversal of opioid-induced tolerance in chronic pain states.
2. The design and synthesis of new conformationally constrained glutathione peroxidase mimetics.
3. The design and synthesis of new molecular scaffolds with combined norepinephrine reuptake and COX-II inhibitory activities.
4. The design and synthesis of selective tissue factor-factor VIIa inhibitors.
Selected Publications:
1. Dorshow, Richard B.; Asmelash, Bethel; Chinen, Lori K.; Debreczeny, Martin P.; Fitch, Richard M.; Freskos, John N.; Galen, Karen P.; Gaston, Kimberly R.; Marzan, Timothy A.; Poreddy, Amruta R.; Rajagopalan, Raghavan; Shieh, Jeng-Jong; Neumann, William L.. New optical probes for the continuous monitoring of renal function. Proceedings of SPIE (2008), 6867(Molecular Probes for Biomedical Applications II)
2. Lee, Nam S.; Neumann, William L.; Freskos, John N.; Marzan, Tim A.; Shieh, Jeng J.; Dorshow, Richard B.; Wooley, Karen L. Photonic shell-crosslinked nanoparticles probes for optical imaging and monitoring. Polymer Preprints (American Chemical Society, Division of Polymer Chemistry) (2008), 49(1), 1051-1052.
3. Trujillo, John I.; Huang, Horng-Chih; Neumann, William L.; Mahoney, Matthew W.; Long, Scott; Huang, Wei; Garland, Danny J.; Kusturin, Carrie; Abbas, Zaheer; South, Michael S.; Reitz, David B.: Design, synthesis, and biological evaluation of pyrazinones containing novel P1 needles as inhibitors of TF/VIIa. Bioorganic & Medicinal Chemistry Letters 2007, 17, 4568-4574.
4. Barbara A. Schweitzer, William L. Neumann, Hayat Rahman, Carrie L. Kusturin, Kirby R. Sample, Gennadiy I. Poda, Ravi G. Kurumbail, Roderick A Stegeman, Anna M. Stevens, William C. Stallings, and Michael S. South. Structure-Based Design of Pyrazinone Antithrombotics Containing Novel P1 “Side Pocket” Moieties as Inhibitors of TF/VIIa, Bioorg. Med. Chem. Lett, 2005, 15, 3006.
5. Parlow, John J.; Case, Brenda L.; Dice, Thomas J.; Hayes, Michael J.; Jones, Darin E.; Neumann, William L.; Lachance, Rhonda M.; Girard, Thomas J.; Nicholson, Nancy J.; Clare, Michael, Stegemen Roderick A.; Stevens, Anna M.; Stallings, William C.; Kurumbail, Ravi G.; South, Michael S. Design, Parallel Synthesis and Crystal Structures of Pyrazinone Antithrombotics as Selective Inhibitors of the Tissue Factor VIIa Complex, J. Med. Chem, 2003, 46, 4050.
6. Kusturin, Carrie K. Liebeskind, Lanny S.; Rahman, Hayat, Sample, Kirby R.; Schweitzer, Barbara A.; Srogl, Jiri, Neumann, William L. Switchable Catalysis: Modular Synthesis of Functionalized Pyrimidinones via Selective Sulfide and Halide Cross-Coupling Chemistry, Organic Letters, 2003, 5, 4349.
7. Kusturin, Carrie L.; Liebeskind, Lanny S.; Neumann, William L. A New Catalytic Cross Coupling Approach for the Synthesis of Protected Aryl and Heteroaryl Amidines, Organic Letters 2002, 4(6), 983-985.
