Assistant Professor of Pharmaceutical Sciences
Organic/Medicinal Chemistry and Chemical Biology
B.S., 1983, University of Missouri Columbia
Ph.D., 1987, University of Missouri St. Louis
Research: Medicinal ChemistryMy laboratory focuses on two main research strategies: 1. The development of new synthetic methodologies specifically geared for the rapid generation of new medicinally active compounds. 2 The generation of synthetic enzyme systems and catalytic antioxidants (prevention of pathology, reversal, rescue).
Areas of primary interest include: Synthetic organic, bioorganic and medicinal chemistry, with major focus areas of metals and metal complexes in biological systems; biological chemistry of reactive oxygen and nitrogen species, metal-mediated cross-coupling chemistry, and synthetic methods development for the total synthesis of biologically important molecules.
Other interest areas include: The synthesis of chemical probes for the study of biological phenomena at the molecular, cellular and organism level; synthesis of functional multi-photon absorbing probes for cellular imaging, the synthesis of conditionally activated smart molecules for biomedical and defense applications; new polymer and nanostructure-based actives delivery systems.
1. The design, synthesis and evaluation of new peroxynitrite decomposition catalysts for the attenuation and reversal of opioid-induced tolerance in chronic pain states.
2. The design and synthesis of peroxynitrite reductase catalysts for pharmaceutical applications.
1. Manganese(III) Complexes of Bis-Hydroxyphenyldipyrromethenes are Potent Orally Active Peroxynitrite Scavengers. Smita Rausaria, Andrew Kamadulski, Nigam P. Rath, Leesa Bryant, Zhoumou Chen, Daniela Salvemini, and William L. Neumann. J. Am. Chem. Soc. 2011, 133, 4200-4203.
2. Daniela Salvemini, Joshua W. Little, Timothy Doyle, William Neumann. “Roles of Reactive Oxygen and Nitrogen Species in Pain.” Free Rad. Biol. Med. 2011, In press.
3. Counter-Regulation of Opioid Analgesia by Glial-Derived Bioactive Sphingolipids. Muscoli C, Doyle T, Dagostino C, Bryant L, Chen Z, Watkins LR, Ryerse J, Bieberich E, Neumman W, Salvemini D. J. Neurosci. 2010, Nov 17;30(46):15400-15408.
4. ω-Oxidation of α-chlorinated fatty acids: Identification of α-chlorinated dicarboxylic acids. Viral V. Brahmbhatt, Carolyn J. Albert, Dhanalakshmi S. Anbukumar, Bryce A. Cunningham, William L. Neumann, David A. Ford, J. Biol. Chem. 2010, 285, 41255-41269.
5. Chlorinated lipid species in activated human neutrophils: lipid metabolites of 2-chlorohexadecanal, Anbukumar, Dhanalakshmi S.; Shornick, Laurie P.; Albert, Carolyn J.; Steward, Melissa M.; Zoeller, Raphael A.; Neumann, William L.; Ford, David A. Journal of Lipid Research 2010, 51(5), 1085-1092.
6. William L. Neumann, Daniela Salvemini. Targeting peroxynitrite driven nitroxidative stress with synzymes: A novel therapeutic approach in chronic pain management, IUBMB Life Sciences, 2010, 86, 604-614.
7 Guorong Sun, Nam S. Lee, William L. Neumann, John N. Freskos, Jeng J. Shieh, Richard B. Dorshow, Karen L. Wooley. A fundamental investigation of cross-linking effieciencies within discrete nanostructures, using the cross-linker as a reporting molecule. Soft Matter, 2009, 5(18), 3422-3429
8. William L. Neumann, Daniela Salvemini. Peroxynitrite: A Strategic Linchpin of Opioid Analgesic Tolerance. Trends in Pharmacological Sciences, 2009, 30, 194-202.
9. Nam S. Lee, Guorong Sun, William L. Neumann, John N. Freskos, Jeng J. Shieh, Richard B. Dorshow, and Karen L. Wooley. Photonic Shell-Crosslinked Nanoparticle Probes for Optical Imaging and Monitoring. Advanced Materials, 2009, 20, 1-5
RC1AR058231 (Challenge Grant) 09/30/09 - 8/31/12
NIH (NIAMS) $431,736 annual direct costs
Targeting the Relief of Chronic Pain with Orally Active Peroxynitrite Decomposition Catalysts Role: P.I.