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School of Education, Health and Human Behavior
School of Education

Dr. Brianne Guilford

Assistant Professor   


PhD, 2013, Anatomy and Cell Biology, University of Kansas Medical Center
MA, 2004, Exercise Physiology, University of Missouri-Columbia
BS, 2000, Biology and Psychology, Northwest Missouri State University

diabetic neuropathy, impact of diet and exercise on cellular mechanisms underlying neurodegenerative disease, mitochondrial dysfunction, diabetes


2608 Vadalabene Center


About Dr. Guilford

Dr. Guilford’s research expertise is in basic biomedical science with focus on investigating mechanisms underlying peripheral nervous system disorders. In addition, Dr. Guilford’s research experience includes human exercise training, weight management, and children’s physical activity interventions. Dr. Guilford has several peer reviewed publications and has presented her research over the past 10 years at numerous national and international conferences including the American College of Sports Medicine (ACSM), Integrative Biology of Exercise, Peripheral Nerve Society, Society for Neuroscience, and Diabetic Neuropathy Study Group. She is a Certified Health Fitness Specialist through the American College of Sports Medicine. Dr. Guilford teaches courses in Advanced Exercise Physiology, Exercise Endocrinology, Exercise for Special Populations, and Exercise Physiology.

Research Profile:

Dr. Guilford’s research interest involves investigating how diet, obesity, dyslipidemia impact the development of neurodegenerative disease. In addition, Dr. Guilford is interested in how exercise can prevent and treat diabetic neuropathy.  Her current work is focused on how a high-fat diet impacts the development of diabetic neuropathy in a mouse model. This project includes assessing inflammatory factors in the neural tissue of mice fed a high-fat diet and examining the impact of the diet on nerve innervation in the skin. In addition, she is currently studying the impact of diet and exercise on a irisin, a novel protein that stimulates the browning of white adipose, which can result in increased energy expenditure. Irisin holds promise as a potential pharmacotherapeutic for obesity treatment.  Dr. Guilford is also working in collaboration with Dr. Chris Herndon from the School of Pharmacy to develop infrared thermography as a tool to assess autonomic nerve dysfunction in various clinical populations.

Publications: (list)

Guilford, B.L. and Wright, D.E. Chewing the fat: Genetic approaches to model dyslipidemia-induced diabetic neuropathy in mice. Experimental Neurology 2013; 248: 504-508. PMID: 23933575

Groover, A.L., Ryals, J.M., Guilford, B.L., Wilson, N.M., Christianson, J.A., and Wright, D.E. Exercise-mediated improvements in painful neuropathy associated with pre-diabetes in mice. Pain 2013; 154 (12): 2658-2667. PMID: 23932909.

Levant, B., Ozias, M.S., Guilford, B.L., and Wright. D.E. Streptozotocin-induced diabetes partially attenuates the effects of a high-fat diet on liver and brain fatty acid composition in mice. Lipids 2013; 48(9): 939-948. PMID: 28933338.

Guilford, B.L., Ryals J.M., Wright, D.E. Phenotypic changes in diabetic neuropathy induced by a high‑fat diet in diabetic C57Bl/6 mice.  Experimental Diabetes Research 2011; 2011:848307. PMID: 2214490.

Saunders, R.R., Saunders, M.D., Donnelly, J.E., Smith, B.R., Sullivan, D.K., Guilford, B., and Rondon, M.F. Evaluation of an approach to weight loss in adults with intellectual or developmental disabilities  Intellectual and Developmental Disabilities, 2011; 49(2): 103-112. PMID: 21446873.

Rector, R.S., Turk, J.R., Sun, G.Y., Guilford, B.L., Toedebusch, B.W., McClanahan, M.W., and Thomas, T.R. Short-term lifestyle modification alters circulating biomarkers of endothelial health in sedentary overweight adults. Applied Physiology, Nutrition, and Metabolism 2006; 31(5): 512-517. PMID: 17111005.

Altena, T.S., Michaelson, J.L., Ball, S.D., Guilford, B.L., and Thomas, T.R. Lipoprotein subfraction changes after continuous or intermittent exercise training. Medicine Science Sports and Exercise 2006; 38(2): 367-372. PMID: 16531908.

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