Dr. Melissa Chan, Dr. Engineering

Assistant Professor

Environmental Sciences Program

College of Arts and Sciences

Southern Illinois University Edwardsville

Science Building West, Room 2200

Edwardsville, Illinois 62026-1651

Phone: 618.650.5786

Fax: 618.650.5102

Email: pchan@siue.edu

 

Education/Training

  • Postdoctoral Visiting Fellow, Biomolecular Screening Branch, National Toxicology Program, National Institute of Environmental Health Sciences, USA, 2010-2011

  • Postdoctoral Visiting Fellow, Environmental Systems Biology, National Institute of Environmental Health Sciences, USA, 2007-2010

  • Postdoctoral Research Fellow/Visiting Research Scientist, Environmental Risk Analysis, Department of Global Environment Engineering, Kyoto University, Japan, 2005-2007

  • Doctor of Engineering (Global Environment Engineering), Kyoto University, Japan, 2005

  • Master of Philosophy (Environmental Chemistry), University of Malaya, Malaysia, 2003

  • Bachelor of Science (Applied Chemistry), University of Malaya, Malaysia, 1999

Professional Appointments

  • Assistant Professor, Southern Illinois University Edwardsville, 2011-Present

  • Guest Researcher, National Toxicology Program, National Institute of Environmental Health Sciences, USA, 2011-Present

  • Graduate Research Assistant, Kyoto University, Japan, 2002-2007

  • Chemist, Ansell Shah Alam Sdn. Bhd., Malaysia, 2002

  • Research Assistant, University of Malaya, Malaysia, 1999-2002

Research Interests

  • Pharmacokinetics and pharmacodynamics

  • Environmental fate/factors and human health impacts

  • Health and environmental risk assessment due to exposure to hazardous chemicals/pollutants and intervention

  • Environmental epidemiology

  • In vitro to in vivo extrapolation

  • Toxicokinetics, neurotoxicology, environmental toxicology

  • Analytical chemistry and instrumentations

Teaching

  • ENSC 528-Analysis of Environmental Contaminants (Spring, 2014 onwards)

  • ENSC 528L-Analysis of Environmental Contaminants Lab (Spring, 2014 onwards)

  • ENSC 575-Statistics for Environmental Sciences (Spring, 2012-Present)

  • ENSC 595-003-Environmental Epidemiology (Fall, 2012-Present)

  • ENSC 505/506-Environmental Sciences Seminar I/II (Fall/Spring, 2011-Present)

  • ENSC 330-Environmental Health and Waste Management (Spring, 2012-Present)
  • ENSC 220L-Principles of Environmental Sciences Lab (Fall, 2011-Present)

  • ENSC 120-Survey of Environmental Sciences (Fall, 2011-Present)

Service

  • Chair, Environmental Science Division, Illinois State Academy of Science; 2012-Present

  • Reviewer/Editorial Board, Journal of Medical Sciences; 2012-Present

  • Invited Scientific Reviewer, International Journal of Environmental Health Research; 3rd Annual International Conference on Sustainable Energy and Environmental Sciences

  • Faculty Fellow, SIUE- Residence Halls; 2012-Present

  • Chair, SIUE Environmental Sciences Program-Committee of Student Evaluation of Teaching; 2012-Present

  • Chair, SIUE Environmental Sciences Program-Safety and Equipment Committee; 2013-Present

  • Committee Member, SIUE Environmental Sciences Program-PSM Program, Graduate Program, SLW Building Safety; 2013-Present

  • Advisor, SIUE Environmental Sciences Program-Environmental Technology and Assessment Section; 2012-2013

  • Advisor, SIUE Environmental Sciences Program-Environmental Education Section; 2013-Present

  • Webmaster, SIUE Environmental Sciences Program website; 2011-Present

Selected Publications (Peer-Reviewed Articles, Books, and Conferences Proceedings)

Peer-Reviewed Articles:(Reprints can be requested via email)

  1. M. F. Hughes, M. P. L. Chan, J. M. Starr, T. J. Shafer, E. J. Scollon, M. J. DeVito. Extrapolating dose in vitro to dose in vivo of a neurotoxic pyrethroid pesticide using empirical approaches and a PBPK model. In: Parameters for Pesticide QSAR and PBPK/PD Models for Human Risk Assessment; Knaak J., et al.; ACS Symposium Series; American Chemical Society: Washington, DC; 2012: 229-241.

  2. M. P. L. Chan, S. Morisawa, A. Nakayama, Y. Kawamoto, M. Yoneda.  Evaluation of health risk due to the exposure to endosulfan in the environment.  AATEX, 2008; Special Issue (14): 543-548.

  3. Y. Kawamoto, W. Matsuyama, M. Wada, Junko Hishikawa, M. P. L. Chan, A. Nakayama, S. Morisawa.  Development of a physiologically based pharmacokinetic model for Bisphenol A in pregnant mice.  Toxicology and Applied Pharmacology, 2007; 224 (2): 182-191.

  4. M. P. L. Chan, S. Morisawa, A. Nakayama, Y. Kawamoto, M. Sugimoto, M. Yoneda.  A physiologically based pharmacokinetic model for endosulfan in the male Sprague-Dawley rats.  Environmental Toxicology, 2006; 21 (5): 464-478.

  5. M. P. L. Chan, S. Morisawa, A. Nakayama, Y. Kawamoto, M. Yoneda.  Development of an in vitro blood-brain barrier model to study the effects of endosulfan on the permeability of tight junctions and a comparative study of the cytotoxic effects of endosulfan on rat and human glial and neuronal cell cultures.  Environmental Toxicology, 2006; 21 (3): 223-235.

  6. M. P. L. Chan, S. Morisawa, A. Nakayama, Y. Kawamoto, M. Sugimoto, M. Yoneda.  Toxicokinetics of 14C-Endosulfan following single and repeated oral administration in male Sprague-Dawley rats.  Environmental Toxicology, 2005; 20 (5): 533-541.

  7. M. P. L. Chan, A. M. Mustafa.  Analysis of endosulfan and its metabolites in rat plasma and selected tissue samples by gas chromatograph-mass spectrometer.  Environmental Toxicology,2005; 20 (1): 45-52.

  8. M. P. L. Chan, A. M. Mustafa, R. Hussein, S. Hj. Hussain, S. N. Zulkifli, A. R. Abdullah.  Pesticide residues in blood of schoolchildren from selected schools in Peninsular Malaysia.  Environmental Health Focus, 2004; 2 (1): 18-24.

  9. M. A. Mohd, M. P. L. Chan, A. R. Abdullah and T. Kitsuwa.  Status and results of EDC monitoring in Malaysia.  Shimadzu Review, 2002; Vol. 59, No. 1.2, pp. 111-126.

  10. M. P. L. Chan, A. R. Abdullah, A. M. Mustafa, B. L. L. Tan, S. N. Zulkifli.  Nationwide assessment of pesticide residues in blood of schoolchildren and monitoring of the water quality from Selangor River, Malaysia.  Asia PacificJournal of Pharmacology, 2001; 15 (2): S54.

  11. M. P. L. Chan, A. R. Abdullah, A. M. Mustafa.  UNU Project on EDCs Pollution in the East Asian Coastal Hydrosphere: The monitoring of phthalates in various rivers in Peninsular Malaysia from December 2001 to February 2002.  UNU International Symposium on Tracing Pollutants from Agrochemical Use:Focus on EDC Pollution, Hanoi, Vietnam, April 15-16, 2002.

Book:

  1. Abdullah, A. R., K. Arumugam, Chan, M. P. L., Mohd, A. M., Pendek, R., Husain, R., Hj. Hussain, S., Mohamed, Z. Endocrine-disrupting chemicals : An overview. Xenobiotic Analysis Series Vol 3, Shimadzu-UMMC Centre for Xenobiotic Studies, University of Malaya, Kuala Lumpur, 2000.

Conferences Proceedings:

  1. M. Chan.  An investigation of factors associated with mortality patterns across the Midwestern United States (#717). In: Proceedings of the Society of Toxicology’s 52nd Annual Meeting, San Antonio, Texas, March 10-14, 2013.

  1. M. P. L. Chan.  Challenges in tools and models used for quantitative extrapolation of in vitro to in vivo toxicity data.  In: Proceedings of the JSPS-US Alumni Association-3rd Multidisciplinary Science Forum (MSF), Chapman University, Orange County, California, February 1, 2013; pp. 25.

  1. M. P. L. Chan, M. F. Hughes, T. J. Shafer, R. Tornero-Velez, M. J. DeVito.  Evaluating tools and models used for quantitative extrapolation of in vitro high throughput screening data to risk management decisions (#1732). In: The Toxicologist CD: An Official Journal of the Society of Toxicology, Volume 126, Issue 1, March 2012.

  1. M. P. L. Chan, M. F. Hughes, T. J. Shafer, R. Tornero-Velez, M. J. DeVito.  Quantitative in vitro to in vivo extrapolation of pyrethroids.  242nd ACS Meeting and Exposition, Denver, Colorado, August 28-September 1, 2011.

  1. M. P. L. Chan, R. S. Weinhold, R. Thomas, J. M. Gohlke, C. J. Portier.  Environmental predictors of U.S. county mortality patterns on a national basis.  In: Proceedings of the JSPS-US Alumni Association-1st Multidisciplinary Science Forum (MSF), Seattle, Washington, March 11-12, 2011; pp. 24.

  1. M. P. L. Chan, R. S. Weinhold, R. Thomas, J. M. Gohlke, C. J. Portier.  Environmental predictors of U.S. county mortality patterns on a national basis (#1567).  In: The Toxicologist CD: An Official Journal of the Society of Toxicology, Volume 120, Supplement 2, March 2011.

  1. Melissa Chan, Xiaoqing Chang, Michael Easterling, Michael DeVito.  Evaluating tools and models used for quantitative extrapolation of in vitro high throughput screening data to risk management decisions.  In: Review of the Biomolecular Screening Branch by the NTP Board of Scientific Counselors, Research Triangle Park, North Carolina, November 30-December 1, 2010; pp. 15.

  1. M. P. L. Chan, R. S. Weinhold, R. Thomas, J. M. Gohlke, C. J. Portier.  Environmental predictors of U.S. county mortality patterns on a national basis (#6).  In: Proceedings of the Toxicity Pathway-Based Risk Assessment: Preparing for a Paradigm Change, Washington DC, May 11-13, 2009; pp. 39.

  1. M. P. L. Chan, R. S. Weinhold, R. Thomas, J. M. Gohlke, C. J. Portier.  Environmental predictors of U.S. county mortality patterns on a national basis (#1470).  In: The Toxicologist CD: An Official Journal of the Society of Toxicology, Volume 108, Number 1, March 2009.

  1. J. M. Gohlke, M. P. L. Chan, C. J. Portier. A systems approach for bridging the gap between human health research and climate change research.  In: Proceedings of the 8th National Conference on Science, Policy and the Environment, Washington DC, January 16-18, 2008; pp. 44.

  1. M. P. L. Chan, Morisawa S., Yoneda M., Nakayama A.  Assessing the health risk following environmental exposure to endosulfan (#1534).  In: The Toxicologist CD: An Official Journal of the Society of Toxicology, Volume 96, Number S-1, March 2007.

  1. M. P. L. Chan, Morisawa S., Yoneda M., Nakayama A.  Assessing the health risk following environmental exposure to endosulfan.  In: Proceedings of the Environmental Toxicity Evaluation and Risk Management, Volume 2; The Second JSPS-VCC Group 4 Seminar on Environmental Toxicity Evaluation and Risk Management, Environmental Risk Management Group of the JSPS-VCC Program on Environmental Science, Engineering and Ethics 2000-2009, Osaka, Japan, November 22-23, 2006; pp. 79-93.

  1. M. P. L. Chan, Morisawa S., Nakayama A., Kawamoto Y., Sugimoto M., Yoneda M.  Development of the health risk assessment framework due to the exposure of endosulfan in the environment (Part 1).  GRC on Environmental Endocrine Disruptors, Il Ciocco, Barga, Italy, June 4-9, 2006.

  1. M. P. L. Chan, Morisawa S., Nakayama A., Kawamoto Y., Yoneda M.  Development of an in vitro blood-brain barrier model to study the permeability of tight junctions and a comparative study of the cytotoxic effects of endosulfan on rat and human glial and neuronal cell cultures (Part 2).  GRC on Environmental Endocrine Disruptors, Il Ciocco, Barga, Italy, June 4-9, 2006.

  1. M. P. L. Chan, Morisawa S., Nakayama A., Kawamoto Y., Sugimoto M., Yoneda M.  A physiologically-based pharmacokinetic model for endosulfan in the male rats.  In: Proceedings of the 11th Asian Chemical Congress; Korea University, Seoul, Korea, August 24-26, 2005; PW98, pp. 220.

  1. M. P. L. Chan, Morisawa S., Yoneda M., Nakayama A.  A physiologically-based pharmacokinetic model for endosulfan in the male rats.  In: Proceedings of the 7th Asian Conference on Analytical Sciences; Hong Kong Baptist University, Hong Kong, SAR, July 28-31, 2004; E025, pp. 258.

  1. M. P. L. Chan, A. M. Mustafa.  Analysis of endosulfan and its metabolites in rat plasma and selected tissue samples by gas chromatograph-mass spectrometer.  In: Proceedings of the 7th Asian Conference on Analytical Sciences; Hong Kong Baptist University, Hong Kong, SAR, July 28-31, 2004; E026, pp. 259.

  1. M. P. L. Chan, A. M. Mustafa, R. Hussein, S. Hj. Hussain, S. N. Zulkifli, A. R. Abdullah.  Pesticide residues in blood of schoolchildren from selected schools in Peninsular Malaysia.  In: Proceedings of the 7th Asian Conference on Analytical Sciences; Hong Kong Baptist University, Hong Kong, SAR, July 28-31, 2004; B025, pp. 258.

  1. A. M. Mustafa, M. P. L. Chan, A. R. Abdullah.  Metabolism and kinetics of endosulfan.  In: Proceedings of the UNU International Symposium on Impacts of POPs from Urban Areas; Beijing, China, May 24-25, 2004.

  1. M. P. L. Chan, A. R. Abdullah, A. M. Mustafa.  Status and results of EDC monitoring in Malaysia.  In: Proceedings of the UNU International Conference: “Conserving Our Coastal Environment: Endocrine-Disruptor Pollution in Asia and the Pacific, Coastal Management and Sustainable Development and Marine Ecology and Environment”; Tokyo, Japan, July 8-10, 2002, pp. 47-74.

  1. M. P. L. Chan, A. R. Abdullah, A. M. Mustafa, S. N. Zulkifli, M. K. Normadiah.  Toxic effects of orally-administered endosulfan in rats.  UNU International Conference: “Conserving Our Coastal Environment: Endocrine-Disruptor Pollution in Asia and the Pacific, Coastal Management and Sustainable Development and Marine Ecology and Environment”; Tokyo, Japan, July 8-10, 2002.

  1. M. P. L. Chan, A. R. Abdullah, A. M. Mustafa, S. N. Zulkifli, M. K. Normadiah.  Toxic effects of orally-administered endosulfan in rats.  UNU International Symposium on Tracing Pollutants from Agrochemical Use: Focus on EDC Pollution, Hanoi, Vietnam, April 15-16, 2002.

  1. A. M. Mustafa, M. P. L. Chan, B. L. L., Tan, A. M. H. Mohamed, A. R. Abdullah.  Monitoring levels of selected pesticides, alkylphenols and phthalates with endocrine - disrupting properties in selected river basins in Malaysia.  In: Proceedings of the UNU International Symposium on Tracing Pollutants from Agrochemical Use: Focus on EDC Pollution, Hanoi, Vietnam, April 15-16, 2002.

  1. Mohd, A. M., Chan, M. P. L., Abdullah, A. R., Zulkifli.  Pesticide residues in blood of schoolchildren from selected schools in Peninsular Malaysia.  In: Proceedings of the UNU International Symposium on Industries and EDC Pollution, Seoul National University, Seoul, Korea, April 16-17, 2001.

  1. Mohd, A. M., Tan, B. L. L., Chan, M. P. L., Abdullah, A. R., Zulkifli, S. N.  EDC Monitoring in Malaysia: A report on pesticide and bisphenols residues in water from the Selangor River.  In: Proceedings of the UNU International Symposium on Industries and EDC Pollution, Seoul National University, Seoul, Korea, April 16-17, 2001.

  2. Mohd, A. M., Chan, M. P. L., Cheng, L. I., Abdullah, A. R., Pesticide residues in water from the Selangor River, Malaysia.  In: Proceedings of the UNU International Symposium on Endocrine-Disrupting Chemicals, University of Malaya, Kuala Lumpur, Malaysia, April 17-18, 2000.