Tuesday 23 February 7:00 PM in the Meridian Ballroom, Morris University Center
"Drug Discovery: Ingenuity or Serendipity?"
Wednesday 24 February 11:00 AM in the Dunham Hall Auditorium
"CPP-115: A novel GABA aminotransferase inactivator and potential new treatment for epilepsy, addiction, and hepatocellular carcinoma"
Professor Silverman’s research can be summarized as investigations of the molecular mechanisms of action, rational design, and syntheses of potential medicinal agents, particularly for neurodegenerative diseases. Professor Silverman has received the highest honors and awards from all over the world including: Fellow of the American Chemical Society, Elected to American Academy of Arts & Sciences, Fellow of the Royal Society of Chemistry (UK), Sato Memorial International Award of the Pharmaceutical Society of Japan , Arthur C. Cope Senior Scholar Award of the American Chemical Society. In addition to international recognition in the academic world professor Silverman is the inventor of Lyrica ™ (pregabalin), marketed worldwide for the treatment of epilepsy, neuropathic pain, fibromyalgia, and (in Europe) for generalized anxiety disorder.
For additional information on the seminar location and times please contact the Chemistry Department.
For directions to the campus please visit the SIUE maps.
"Stabilization of Highly Reactive Molecules"
"Molecules That Changed History"
Professor Robinson is an internationally known organometallic synthetic chemist. His research involves the synthesis and characterization of compounds containing main group elements with unique bonding characteristics (particularly those of groups 13 and 14). The Robinson group has gained wide recognition for their work involving multiple bonds between elements such as gallium and lead. In 2008 the Robinson group discovered a new base-stabilized soluble allotrope of elemental silicon that contains a Si-Si double bond. Professor Robinson has published ~150 peer-reviewed journal articles and six book chapters. He is the author/editor of a book on the Coordination Chemistry of Aluminum. Professor Robinson has received numerous awards for his work including the National Science Foundation's Award for Special Creativity, the Alexander von Humboldt—Stiftung Research Fellowship, and the F. Albert Cotton Award in Synthetic Inorganic Chemistry from the American Chemical Society.
"Recent Advances in Catalytic Asymmetric Synthesis"
"Surprises and Discoveries with Human-Derived Natural Products and Their Relevance to Human Medicine"
Professor Carreira (ETH Zürich) is recognized for the discovery and development of novel strategies for synthesis. This interdisciplinary work demands effective integration of the tools, concepts, and methods of molecular recognition, inorganic, organometallic, and organic chemistry. Areas of investigation include development of processes for asymmetric synthesis, design of catalysts for use in aqueous media, laboratory syntheses of complex natural products, and identification of novel small molecule building blocks that are beneficial to the drug discovery process. Professor Carreira has authored over 230 publications and 30 patents, and has received numerous awards, including the European Research Commission Award, the ACS Award for Creative Work in Synthetic Organic Chemistry, and the American Chemical Society Award in Pure Chemistry. Together with colleagues at ETH Zürich, he has co-founded Lipideon, SpiroChem, and Glycemicon, and is a consultant for companies in North America, Europe, Asia, and Africa.
" Coordination Chemistry and Molecular Recognition in a Supramolecular Container Molecule "
" Nitrogen and Phosphorus: Fertilizer from the Atmosphere to the Oceans "
Professor Cummins's work in inorganic chemistry has been recognized by numerous prestigious organizations. He has had a remarkable career, graduating with a Ph.D. from MIT in 1993 and being immediately hired by MIT as an assistant professor. By 1996 he was promoted to the rank of professor. So far in his 20-year career he is the author of over 150 research articles, advisor to 21 Ph.D. graduates, and serves on the boards of many of the most important inorganic chemistry journals. He has been the recipient of Harvard University's E. Bright Wilson Prize, the ACS Award in Pure Chemistry, the NSF Alan T. Waterman Award, an Alexander von Humboldt Research Award, the Dannie-Heineman Preis of the Akademie der Wissenschaften zu Göttingen, the ACS F. Albert Cotton Award in Synthetic Inorganic Chemistry, and the Raymond and Beverly Sackler Prize in the Physical Sciences. Dr. Cummins has been elected to membership in the American Academy of Arts and Sciences, and is a corresponding member of the Akademie der Wissenschaften zu Göttingen. He is also a Fellow of the Royal Society of Chemistry. In February prior to the Probst Lecture, it was announced that Dr. Cummings was the winner of the inaugural Inorganic Chemistry Lectureship Award from the ACS Division of Inorganic Chemistry. Dr. Cummins was nominated by his peers for his creativity, rigor and record of research success in the field of inorganic chemistry.
" Rotavirus and Host-Cell Glycan Interactions "
" Viruses in the 21st Century - an Alternative Approach to Tackling Viral Diseases "
Prof. Itzstein (Griffith University, Brisbane, Australia) is a world wide recognized scientist who has international standing in glycoscience and drug discovery especially in the area of anti-infective drug discovery. His research team designed the synthesis of Relenza®, which is currently used as anti-influenza drug. This discovery is a milestone and at the same time a starting point for the use of carbohydrates and carbohydrate-recognising proteins as drug discovery targets. Relenza® is also the first 'designer' anti-viral drug in the world.
Prof. Mark Von Itzstein established and heads the Institute for Glycomics at Griffith University, which is the only multidisciplinary glycoscience research centre in Australia. His research accomplishments and the relevant contributions to drug design and discovery are internationally recognized by the whole scientific community. The number of his publications, book chapters and invited papers, in addition to the awards received validate the impact of his scientific contributions.
"Water Sustainability in a Changing World"
"Phytoremediation from Molecular to Field Scale"
Professor Jerald Schnoor is a member of the National Academy of Engineering for his pioneering work using mathematical models in science policy decisions. He testified several times before Congress on the environmental effects of acid deposition and the importance of passing the 1990 Clean Air Act. While serving as Editor-in-Chief of Environmental Science and Technology, Jerry guides the leading journal in the world in both environmental engineering and environmental science. His editorial writings on environmental policy and research have been widely accessed by the international community. Professor Schnoor has published (as author, co-author, or editor) six books and over 150 research articles in archival journals, in addition to serving as lead editor of a series of texts and monographs.
Professor Schnoor and his students have pioneered phytoremediation, the use of plants to help clean the environment. The research involves discovering novel pathways for the uptake, storage, and metabolism of toxic organic chemicals at waste sites. Schnoor's publications cover a wide range of environmental problems including toxic chemical fate and transport, surface and groundwater contaminant modeling, phytoremediation, and carbon sequestration for mitigation of greenhouse gases. Over the past three years, Jerry has developed a novel course at the University of Iowa on sustainable environmental systems and has worked closely with students in Engineers for a Sustainable World (ESW).
"Models, Methods, and Machines for Chemical Measurements"
"Teaching and Research: Symbiosis or Conflict?"
Gary M. Hieftje is Distinguished Professor and Mann Chair of Chemistry at Indiana University in Bloomington, Indiana. His research interests include the investigation of basic mechanisms in atomic emission, absorption, fluorescence and mass spectrometric analysis, and the development of instrumentation and techniques for atomic methods of analysis. He is interested also in the on-line computer control of chemical instrumentation and experiments, the use of time-resolved luminescence processes for analysis, the application of information theory to analytical chemistry, analytical mass spectrometry, near-infrared reflectance analysis, and the use of stochastic processes to extract basic and kinetic chemical information. He has won numerous awards in the fields of analytical chemistry and spectroscopy, has held major offices in several scientific societies, and has served on the editorial boards of many major journals. He is the author of over 500 publications, 10 books, and 15 patents. More than 65 students have received doctorates under his direction.
"Protein Folding Dynamics"
"Searching for a Cure for Sickle Cell Disease"
William A. Eaton is the distinguished investigator and the Chief of Laboratory of Chemical Physics at National Institute of Diabetics and Digestive and Kidney Diseases (NIDDK) of National Institutes of Health (NIH) and the scientific director of intramural AIDS Targeted Antiviral Program of the Office of the director at NIH. Dr. Eaton received both M.D. and Ph.D. degrees from the University of Pennsylvania in 1964 and 1967. He was an NIH Postdoctoral Fellow from 1968 to 1972. His research focuses on kinetics, dynamics, and mechanisms of protein folding using pulsed laser methods, single molecule spectroscopy, theoretical models, and computer simulations; physical chemistry of sickle cell hemoglobin polymerization and high through-put screening for the drugs for sickle cell disease; cooperative interactions in multi-subunit proteins. Among the awards Dr. Eaton has received are the Founders Award of Biophysical Society (2006) and Gordon G. Hammes ACS Biochemistry Lectureship (2009). He has been the Fellow of the American Association for the Advancement of Science and American Biophysical Society, and member of National Science of Academy. Dr. Eaton has served on a number of editorial boards, including Proceedings of the National Academy of Science (PNAS), Chemical Physics, and Journal of Physical Chemistry. He has published more than 140 prestigious publications, given hundreds of seminars, and has received recognition from chemistry, biochemistry, and biophysical societies.
C. Dale Poulter is the John A. Widtsoe Distinguished Professor in the Department of Chemistry at the University of Utah. He earned his B.S. in 1964 from Louisiana State University and his Ph.D. in 1967 from the University of California, Berkeley. He was an NIH Postdoctoral Fellow from 1967 to 1969 with Saul Winstein at the University of California, Los Angeles. Dr. Poulterπs research combines synthetic and mechanistic organic chemistry with biochemistry and molecular biology to study the chemistry of enzyme catalysis. This work has focused on enzymes in the isoprenoid biosynthetic pathway, including those in sterol biosynthesis and protein prenylation.
Among the awards Poulter has received are an Alfred P. Sloan Fellowship (1975), the American Chemical Society Ernest Guenther Award (1991), an ACS Arthur C. Cope Scholar Award (1998), the ACS Repligen Award (2002), and the ACS James Flack Norris Award (2004). He is a Fellow of the American Association for the Advancement of Science and the American Academy of Arts and Sciences. Dr. Poulter has served on a number of ACS committees, NIH review panels, and editorial advisory boards. He has held several different offices in the Organic and Biological Divisions of ACS and served as an Associate Editor for the Journal of Organic Chemistry and for Organic Letters. Dr. Poulter is currently Editor-in-Chief of the Journal of Organic Chemistry. He has consulted in the pharmaceutical industry and is a founding scientist of two start-up companies.
The Probst Lecture Series
The Department of Chemistry of Southern Illinois University Edwardsville (SIUE) initiated the Probst Lecture series in 1975 as a memorial to one of its founding faculty members, Professor William J. Probst. Each year a noted chemist is invited for a visit that features several lectures. An evening lecture usually consists of a topic that is broad in scope to attract the interest of alumni, faculty, and students throughout the arts and sciences, while a second afternoon lecture focuses on the guest's contributions to chemical research. In recent years, the lecture series has been planned to coincide with the Chemistry Senior Assignment Poster Session and the Student Research Symposium.
|2015||Dr. Gregory H. Robinson, Molecules That Changed History|
|2014||Dr. Erick M. Carreira, Surprises and Discoveries with Human-Derived Natural Products and Their Relevance to Human Medicine|
|2013||Dr. Christopher Cummins, Nitrogen and Phosphorus: Fertilizer from the Atmosphere to the Oceans|
|2012||Dr. Mark Von Itzstein, Viruses in the 21st Century - an Alternative Approach to Tackling Viral Diseases|
|2011||Dr. Jerald Schnoor, Water Sustainability in a Changing World|
|2010||Dr. Gary M. Hieftje, Teaching and Research: Symbiosis or Conflict?|
|2009||Dr. William A. Eaton, Searching for a Cure for Sickle Cell Disease|
|2008||Dr. Dale C. Poulter, The Terpenome. A Cornucopia of Natural Molecules for Life, Health, and Commerce|
|2007||Ms. Susan Marie Frontczak, Manya: A Living History of Marie Curie|
|2006||Dr. René Roy, Carbohydrates and Biological Recognition: Impact on the Development of Vaccines|
|2005||Dr. Robert F. Curl, The Discovery of the Fullerenes and the New World of Carbon Chemistry|
|2004||Dr. Bassam Z. Shakhashiri, Science is Fun|
|2003||Dr. George B. Richter-Addo, Small, Versatile, and Potent: NO and You|
|2002||Dr. William R. Heineman, Chemistry Sensors: Why They Are Important to You|
|2001||Dr. Purnendu K. Dasgupta, Science and Scientists: Culpability and the passage of innocence|
|2000||Dr. Allen J. Bard, Cold Fusion and Pathological Science|
|1999||Dr. Janet Osteryoung, Research: Who Pays and Who Benefits|
|1998||Dr. Ronald Breslow, The Chemistry of Tomorrow will Change Our World|
|1997||Dr. Fred Basolo, The Early History of Metal Complexes to Illustrate How Science Works|
|1996||Dr. Alfred Bader, The Adventures of a Chemist Collector|
|1995||Dr. Roald Hoffmann, The Same and Not the Same: the Rift Between the Sciences and Humanities|
|1994||Dr. Terence C. Owen, Pretty Colored Chemistry for Biology and Medicine: Better Things for Better Living|
|1993||Dr. Frederick Hawthorne, Boron Neutron Capture Therapy|
|1992||Dr. Harold Kroto, C60, Buckminsterfullerene, The Celestial Sphere Which Fell to Earth|
|1991||Dr. James L. Dye, Electride Structures|
|1990||Dr. Lawrence K. Montgomery, Organic Superconductors? You Must Be Kidding|
|1989||Dr. Norman R. Farnsworth, Prospects for Finding Anticancer Drugs from Plants and Marine Organisms|
|1988||Dr. Peter Kollman, Use of Computer Simulations in Chemistry|
|1987||Dr. John William Birks, Nuclear Winter - Ultraviolet Spring|
|1986||Dr. Jacqueline K. Barton, Molecular Travels Along the DNA Strand|
|1985||Dr. Paul Gassman, How to Bend a Carbon-Carbon Bond|
|1983||Dr. Michael Kasha, A New Look at the History and Design of String Instruments: Guitar, Viola, Violin|
|1982||Dr. Leo A. Paquette, The Dodecahedron Story|
|1981||Dr. Mildred Cohn, Nuclear Probes of Enzymatic Reactions|
|1980||Dr. William N. Lipscomb, How Do Enzymes Work?|
|1979||Dr. Carl Djerassi, The Future of Human Birth Control|
|1978||Dr. Melvin S. Newman, New Chemistry Involved in Studies on Synthesis of Carcinogenic Compounds|
|1977||Dr. Paul D. Bartlett, Competing Reaction Mechanisms in Organic Oxidation|
|1976||Dr. Robert E. Buckles, Halogen Addition Reactions: Simple Reactions Which Are Not So Simple|