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Yun Lu

Professor, Organic Chemistry
Department of Chemistry
Southern Illinois University Edwardsville
College of Arts and Sciences
SL 2337 (Office) | 2210 (Lab)
Edwardsville, Illinois 62026-1652.
Tel: (618) 650-3563 (Office) | (618) 650-3568 (Lab)
Fax: (618) 650-3556

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Research Interests:

My overall research centers on the mechanistic understandings of organic and biology-related reactions employing mechanistic analysis methodologies. Current research include (i) structure-reactivity-mechanism relationship for hydride transfer reactions from alcohols to organic carbocations and (ii) biomimetic chemistry studies of the alcoholic oxidations by NAD+ coenzyme mediated by alcohol dehydrogenases.

Selected Publications:

  • Yun Lu, Fengrui Qu, Brian Moore, Donald Endicott, William Kuester "Hydride Reduction of NAD+ Analogues by Isopropyl Alcohol: Kinetics, Deuterium Isotope Effects and Mechanism" J. Org. Chem. (Featured Article) 2008, 73, 4763.

  • Yun Lu, Donald Endicott, William Kuester "Effective Oxidation of Isopropanol by an NAD+ Model." Tetrahedron Letters 2007, 48, 6356.

  • Yun Lu, Jiancheng Liu, Garry Diffee, Diansheng Liu, Bo Liu "Reduction of Nitroarenes by Hydroxide Ion in Water Catalyzed by β-Cyclodextrin: Enhanced Reactivity of Hydroxide Ion." Tetrahedron Letters 2006, 47, 4597.

  • Martin Newcomb, Runnan Shen, Yun Lu, Minor J. Conn, Paul F. Hollenberg, Daniel A. Kopp, Stephen J. Lippard "Evaluation of norcarane as a probe for radicals in cytochrome P-450 and soluble Methane Monooxygenase- catalyzed hydroxylation reactions" J. Am. Chem. Soc. 2002, 124, 6879.

  • Yun Lu, Yixing Zhao, Vernon D. Parker "Proton-transfer reactions of methylarene radical cations with pyridine bases under non-steady-state conditions. Real kinetic isotope effect evidence for extensive tunneling" J. Am. Chem. Soc. 2001, 123, 5900.

  • Jin-Pei Cheng, Yun Lu, Xiaoqing Zhu, Linjing Mu "Energetics of Multi-step vs. One-step Hydride Transfer Reactions of Reduced Nicotinamide Adenine Dinucleotide (NADH) Models with Organic Cations and p-Quinones" J. Org. Chem. 1998, 63, 6108.

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