My overall research centers on the mechanistic understandings of organic and biology-related reactions employing mechanistic analysis methodologies. Current research include (i) structure-reactivity-mechanism relationship for hydride transfer reactions from alcohols to organic carbocations and (ii) biomimetic chemistry studies of the alcoholic oxidations by NAD+ coenzyme mediated by alcohol dehydrogenases.
Yun Lu, Fengrui Qu, Brian Moore, Donald Endicott, William Kuester “Hydride Reduction of NAD+ Analogues by Isopropyl Alcohol: Kinetics, Deuterium Isotope Effects and Mechanism” J. Org. Chem. (Featured Article) 2008, 73, 4763.
Yun Lu, Donald Endicott, William Kuester “Effective Oxidation of Isopropanol by an NAD+ Model.” Tetrahedron Letters 2007, 48, 6356.
Yun Lu, Jiancheng Liu, Garry Diffee, Diansheng Liu, Bo Liu “Reduction of Nitroarenes by Hydroxide Ion in Water Catalyzed by β-Cyclodextrin: Enhanced Reactivity of Hydroxide Ion.” Tetrahedron Letters 2006, 47, 4597.
Martin Newcomb, Runnan Shen, Yun Lu, Minor J. Conn, Paul F. Hollenberg, Daniel A. Kopp, Stephen J. Lippard “Evaluation of norcarane as a probe for radicals in cytochrome P-450 and soluble Methane Monooxygenase- catalyzed hydroxylation reactions” J. Am. Chem. Soc. 2002, 124, 6879.
Yun Lu, Yixing Zhao, Vernon D. Parker “Proton-transfer reactions of methylarene radical cations with pyridine bases under non-steady-state conditions. Real kinetic isotope effect evidence for extensive tunneling” J. Am. Chem. Soc. 2001, 123, 5900.
Jin-Pei Cheng, Yun Lu, Xiaoqing Zhu, Linjing Mu “Energetics of Multi-step vs. One-step Hydride Transfer Reactions of Reduced Nicotinamide Adenine Dinucleotide (NADH) Models with Organic Cations and p-Quinones” J. Org. Chem. 1998, 63, 6108.