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Biological Sciences

Dr. Kyong Sup Yoon

Portrait of Dr. Kyong Sup YoonAssistant Professor

Ph.D. University of Massachusetts, 2006

Office: SLW 2180
Research Lab: SLW 2120
Phone: (618) 650-3302
E-mail: kyoon@siue.edu

 

Courses Taught: Contemporary Biology (BIOL 111), Toxicology (ENSC 531/CHEM 471), Environmental Sciences Seminar I/II (ENSC 505/506).

Research Interests: My main research interests span a spectrum of environmental toxicology and vector biology to protect agriculture, animal and human health in environmentally safe, sustainable and affordable ways. I am particularly interested in the following areas of interdisciplinary research: (1) vector biology investigations using arthropod vector models, (2) adverse effects of insecticide exposure on humans and other non-target organisms, (3) mode of action and neurophysiological effects of natural and synthetic insecticides, (4) genetic and epigenetic mechanisms of insecticide resistance in arthropod pests, and (5) biochemical and molecular diagnostics using high throughput enzyme assays and SNP detections for pest management.

Research Opportunities: For inquiries, please contact me.

Selected Publications

Clark, J. M., Yoon, K.-S., Kim, J. H., Lee, S. H., Pittendrigh, B. R. (2014) Utilization of the human louse genome to study insecticide resistance and innate immune response. Pesticide biochemistry and physiology, DOI:10.1016/j.pestbp.2014.11.008.

Gellatly, K. J., Yoon, K.-S., Doherty, J. J., Sun, W., Pittendrigh, B. R., Clark, J. M. (2014) RNAi validation of resistance genes and their interactions in the highly DDT-resistant 91-R strain of Drosophila melanogaster. Pesticide biochemistry and physiology, DOI:10.1016/j.pestbp.2015.01.001.

Yoon, K. S., Previte, D. J., Hodgdon, H. E., Pool, B. C., Kwon, D. H., Aboelghar, G. E., Lee, S. H., Clark, J. M. (2014) Knockdown resistance allele frequencies in North American head louse populations. J. Med. Entomol. 51:450-457.

Previte, D. J., Olds, B. P., Yoon, K. S., Sun, W., Muir, B., Paige, K. N., Lee, S. H., Clark, J. M., Pittendrigh, B. R. (2014) Differential gene expression in laboratory strains of human head and body lice when challenged with Bartonella quintana, a disease causing bacterium. Insect Mol. Biol. 23:244-254.

Kwon, D. H., Kim, J. H., Yoon, K. S., Clark, J. M., Lee, S. H. (2014) Identification and characterization of the esterase involved in malathion resistance in the head louse, Pediculus humanus capitis. Pestic. Biochem. Physiol. 112:13-18.

Kim, J., Park, Y., Yoon, K. S., Clark, J. M., Park, Y. (2014) Permethrin alters adipogenesis in 3T3-L1 adipocytes and causes insulin resistance in C2C12 myotubes. J. Biochem. Mol. Toxicol. 28:418-424.

Hardstone, M. C., Strycharz, J. P., Kim, J., Park, I. -K., Yoon, K. S., Ahn, Y. J., Harrington, L. C., Lee, S. H., Clark, J. M. (2014) Development of multi-functional metabolic synergists to suppress the evolution of resistance against pyrethroids in insects that blood feed on humans. Pest Manag. Sci. DOI: 10.1002/ps.3856.

Clark, J. M., Yoon, K. S., Lee, S. H., Pittendrigh, B. R. (2013) Human lice: Past, present and future control. Pestic. Biochem. Physiol. 106:162-171.

Pittendrigh, B. R., Olds, B., Yoon, K. S., Lee, S. H., Sun, W., Clark, J. M. (2013) The genomics of human lice: From the genome to the potential for future control strategies. Pestic. Biochem. Physiol. 106:172-176.

Abromaitis, S., Nelson, C. S., Previte, D. J., Yoon, K. S., Clark, J. M., DeRisi, J. L., Koehler, J. E. (2013) Bartonella quintana deploys host and vector temperature-specific transcriptomes. PLoS ONE 8 (3):e58773.

Kim, J., Park, Y., Yoon, K. S., Clark, J. M., Park, Y. (2013) Imidacloprid, a neonicotinoid, induces insulin resistance. J. Toxicol. Sci. 38:655-660.

Strycharz, J. P., Lao, A., Li, H., Qiu, X., Lee, S. H., Sun, W., Yoon, K. S., Pittendrigh, B. R., Clark, J. M. (2013) Polygenic resistance in the highly DDT-resistant 91-R strain of Drosophila melanogaster involves decreased penetration, increased metabolism, and direct excretion. Pestic. Biochem. Physiol. 107:207-217.

Olds, B. P., Coates, B. S., Steele, L. D., Sun, W., Agunbiade, T. A., Yoon, K. S., Strycharz, J. P., Lee, S. H., Paige, K. N., Clark, J. M., Pittendrigh, B. R. (2012) Comparison of the transcriptional profiles of head and body lice. Insect Mol. Biol. 21:257-268.

Kim, J. H., Yoon, K. S., Previte, D. J., Pittendrigh, B. R., Clark, J. M., Lee, S. H. (2012) Comparison of the immune responses in the alimentary track tissues between body versus head lice following Escherichia coli oral infection. J. Asia Pac. Entomol. 15:409-412.

Park, Y., Kim, Y., Kim, J., Yoon, K. S., Clark, J. M., Lee, J., Park, Y. (2012) Imidacloprid, a neonicotinoid insecticide, potentiates adipogenesis in 3T3-L1 adipocytes. J. Agric. Food Chem. 61:255-259.

Kim, J. H., Min, J. S., Kang, J. S., Kwon, D. H., Yoon, K. S., Strycharz, J. P., Koh, Y. H., Pittendrigh, B. R., Clark, J. M., Lee, S. H. (2011) Comparison of the humoral and cellular immune responses between body and head lice following bacterial challenge. Insect Biochem. Mol. Biol. 41:332-339.

Yoon, K. S., Strycharz, J. P., Baek, J. H., Sun, W., Kim, J. H., Kang, J. S., Pittendrigh, B. R., Lee, S. H., Clark, J. M. (2011) Brief exposures of human body lice to sub-lethal amounts of ivermectin over transcribes detoxification genes involved in tolerance. Insect Mol. Biol. 20.:687-699.

Pittendrigh, B. R., Berenbaum, M. R., Seufferheld, M. J., Margam, V. M., Strycharz, J. P., Yoon, K. S., Sun, W., Reenan, R., Lee, S. H., Clark, J. M. (2011) Simply, simply. Lifestyle and compact genome of the body louse provide a unique functional genomics opportunity. Commun. Intergr. Biol. 4 (2):1-4.

Marcuox, D., Palma, K. G., Kaul, N., Hodgdon, H., VanGeest, A., Previte, D. J., Abou-Elghar, G. E., Yoon, K. S., Clark, J. M. (2010) Pyrethroid pediculicide resistance of head lice in Canada evaluated by serial invasive signal amplification reaction. J. Cutan. Med. Surg. 14:115-118.

Seong, K. M., Lee, D. Y., Yoon, K. S., Kwon, D. H., Kim, H. C., Klein, T. A., Clark, J. M., Lee, S. H. (2010) Establishment of quantitative sequencing and residual filter vial bioassays for the monitoring of pyrethroid resistance in the common bed bug, Cimex lectularius L. J. Med. Entomol. 47:592-599.

Kwon D. H., Yoon K. S., Clark J. M. and Lee S. H. (2010) A point mutation on glutamate-gated chloride channel confers abamectin resistance in the two-spotted spider mite, Tetranychus urticae Koch. Insect Mol Biol. 19:583-591.

Kirkness, E. F., Haas, B. J., Sun, W., Braig, H. R., Perotti, M. A., Clark, J. M., Lee, S. H., Robertson, H. M., Kennedy, R. C., Elhaik, E., Gerlach, D., Kriventseva, E. V., Elsik, C. G., Graur, D., Hill, C. A., Veenstra, J. A., Tubío, J. M. C., Ribeiro, J. M. C., Rozas, J., Unger, M. F., Christley, S., J. Johnston, S., Reese, J. T., Popadic, A., Tomoyasu, Y., Tojoo, M., Raoult, D., Reed, D. L., Krause, E., Mittapalli, O., Margam, V. M., Li, H. -M., Meyer, J. M., Johson, R., Romero-Severson, J., VanZee, J. P., Alvarez-Ponce, D., Vieira, F. G., Aguadé, M., Guirao-Rico, S., Anzola, J. M., Yoon, K. S., Strycharz, J. P., Tojo, M., Lobo, N. F., Dasch, G. A., Struchiner, C. J., Madey, G., Hannick, L. I., Bidwell, S., Joardar, V., Caler, E., Shao, R., Barker, S., Cameron, S., Bruggner, R. V., Regier, A., Johnson, J., Viswanathan, L., Utterback, T. R., Strausberg, R. L.,  Walenz, B., Sutton, G. G., Lawson, D., Waterhouse, R., Venter, J., C., Berenbaum, M., Collins, F. H., Zdobnov, E. M.,  Pittendrigh, B. R. (2010) Genome sequences of the human body louse and its primary endosymbiont provide insights into the permanent parasitic lifestyle. Proc. Natl. Acad. Sci. U.S.A. 107:12168-12173.

Hodgdon, H. E., Yoon, K. S., Previte, D. J., Kim, H. J., Aboelghar, G. E., Lee, S. H., Clark, J. M. (2010) Monitoring knockdown resistance allele frequencies in global human head louse populations using the serial invasive signal amplification reaction. Pest Manag. Sci. 66:1031-1040.

Lee, S. H., Min, J. S., Yoon, K. S., Strycharz, J. P., Johnson, R., Mittapalli, O., Margam, V. M., Sun, W., Li, H. -M., Xie, J., Wu, J., Berenbaum, M. R., Pittendrigh, B. R., and Clark, J. M. (2010) Decreased detoxification genes and genome size makes the human body louse an efficient model to study insecticide resistance. Insect Mol. Biol. 19:599-615.

Lee, S. H., Clark, J. M., Ahn, Y. J., Lee, W. -J., Yoon, K. S., Kwon, D. H., Seong, K. M. (2010) Molecular mechanisms and monitoring of permethrin resistance in human head lice. Pestic. Biochem. Physiol. 97:109-114.

Clark, J. M., Lee, S. H., Yoon, K. S., Strycharz, J. P., and Kwon, D. H. “Human Head Lice: Status, Control and Resistance.” In, Advances in Human Vector Control. Editors J. M. Clark, J. R. Bloomquist, and H. Kawada. ACS Symposium Series Vol. 1014. ACS Books, Washington D. C. 2009. pp 73-88.

Lee, S. H., Clark, J. M., Yoon, K. S., Kwon, D. H., Hodgdon, H. E., and Seong, G. M. “Resistance Management of the Human Head Louse Using Molecular Tools.” In, Advances in Human Vector Control. Editors J. M. Clark, J. R. Bloomquist, and H. Kawada. ACS Symposium Series Vol. 1014. ACS Books, Washington D. C. 2009. pp 203-215.

Lee, S. H., Yoon, K. S., Gao, J. -R, Ahn, Y. -J, and Clark, J. M. “Control and Resistance Management of Human Pediculosis.” In, New Discoveries in Agrochemicals. Editors J. M. Clark and H. Ohkawa. ACS Symposium Series Vol. 892, ACS, Washington D. C. 2004. pp. 383-393.

Clark, J. M., Lee, S. H., Kim, H. -J., Yoon, K. S. and Zhang, A. "Molecular Approaches to Insect Resistance Management." In,  Agrochemical Resistance: Extent, Mechanism, and Detection. Editors J.M. Clark and I. Yamaguchi. ACS Symposium Series Vol. 808, ACS Books, Washington D.C. 2001. pp. 103-125.

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